The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains
Abstract The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment ind...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 2008-11, Vol.204 (1), p.43-51 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 51 |
|---|---|
| container_issue | 1 |
| container_start_page | 43 |
| container_title | Journal of neuroimmunology |
| container_volume | 204 |
| creator | Yasuda, Y Shimoda, T Uno, K Tateishi, N Furuya, S Yagi, K Suzuki, K Fujita, S |
| description | Abstract The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-γ, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP. |
| doi_str_mv | 10.1016/j.jneuroim.2008.08.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19512964</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165572808003573</els_id><sourcerecordid>19512964</sourcerecordid><originalsourceid>FETCH-LOGICAL-c518t-223fcc7501d2f8726152033fa101aacaf0355499a802b837e57f8e1b41e7a98b3</originalsourceid><addsrcrecordid>eNqFkU1vGyEQhlHUKHHd_oWIU29r87F42UvVKmrTSKkSqe4ZYXZo2OxCCqwl__uysaNKvVQaiQHedwaeQeiKkhUldLPuV72HKQY3rhghcjUH4WdoQWXDKlkz-gYtilBUomHyEr1NqSeECl63F-iSSkmbVtYLNG0fAYO1YHLCweLvD9sHHDzO5Vib7PY6u7ItN6MzMfwanF7rlGMwhwwJa9_hkoUn52FtHmF8yfAAexgSdh53rtSO4PPsB1yc2vn0Dp1bPSR4f1qX6OfXL9vrb9Xd_c3t9ee7yggqc8UYt8Y0gtCO2fKvDRWMcG51QaC10ZZwIeq21ZKwneQNiMZKoLuaQqNbueNL9OFY9zmG3xOkrEaXDAyD9hCmpGgrKGs3dRFujsLyx5QiWPUc3ajjQVGiZuCqV6_A1QxczVHeskRXpw7TboTur-1EuAg-HQUFCOwdRJWMA2-gc7FAV11w_-_x8Z8SZnDeGT08wQFSH6boC0VFVWKKqB_z2OepE1ncouH8D6AVq3g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19512964</pqid></control><display><type>article</type><title>The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Yasuda, Y ; Shimoda, T ; Uno, K ; Tateishi, N ; Furuya, S ; Yagi, K ; Suzuki, K ; Fujita, S</creator><creatorcontrib>Yasuda, Y ; Shimoda, T ; Uno, K ; Tateishi, N ; Furuya, S ; Yagi, K ; Suzuki, K ; Fujita, S</creatorcontrib><description>Abstract The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-γ, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2008.08.003</identifier><identifier>PMID: 18817984</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology ; Allergy and Immunology ; Analysis of Variance ; Animals ; Astrocytes - drug effects ; Chemokine ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Cytokine ; Cytokines - blood ; Cytokines - cerebrospinal fluid ; Drug Administration Schedule ; Glia ; Male ; Mice ; Mice, Inbred Strains ; Microglia - drug effects ; Movement - drug effects ; MPTP sensitivity ; Nerve Growth Factors - metabolism ; Neurology ; Neurotoxins - pharmacology ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins - metabolism ; Species Specificity ; Strain difference ; Time Factors ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>Journal of neuroimmunology, 2008-11, Vol.204 (1), p.43-51</ispartof><rights>Elsevier B.V.</rights><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-223fcc7501d2f8726152033fa101aacaf0355499a802b837e57f8e1b41e7a98b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572808003573$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18817984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasuda, Y</creatorcontrib><creatorcontrib>Shimoda, T</creatorcontrib><creatorcontrib>Uno, K</creatorcontrib><creatorcontrib>Tateishi, N</creatorcontrib><creatorcontrib>Furuya, S</creatorcontrib><creatorcontrib>Yagi, K</creatorcontrib><creatorcontrib>Suzuki, K</creatorcontrib><creatorcontrib>Fujita, S</creatorcontrib><title>The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-γ, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP.</description><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology</subject><subject>Allergy and Immunology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Astrocytes - drug effects</subject><subject>Chemokine</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Cytokine</subject><subject>Cytokines - blood</subject><subject>Cytokines - cerebrospinal fluid</subject><subject>Drug Administration Schedule</subject><subject>Glia</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Microglia - drug effects</subject><subject>Movement - drug effects</subject><subject>MPTP sensitivity</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Neurology</subject><subject>Neurotoxins - pharmacology</subject><subject>S100 Calcium Binding Protein beta Subunit</subject><subject>S100 Proteins - metabolism</subject><subject>Species Specificity</subject><subject>Strain difference</subject><subject>Time Factors</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vGyEQhlHUKHHd_oWIU29r87F42UvVKmrTSKkSqe4ZYXZo2OxCCqwl__uysaNKvVQaiQHedwaeQeiKkhUldLPuV72HKQY3rhghcjUH4WdoQWXDKlkz-gYtilBUomHyEr1NqSeECl63F-iSSkmbVtYLNG0fAYO1YHLCweLvD9sHHDzO5Vib7PY6u7ItN6MzMfwanF7rlGMwhwwJa9_hkoUn52FtHmF8yfAAexgSdh53rtSO4PPsB1yc2vn0Dp1bPSR4f1qX6OfXL9vrb9Xd_c3t9ee7yggqc8UYt8Y0gtCO2fKvDRWMcG51QaC10ZZwIeq21ZKwneQNiMZKoLuaQqNbueNL9OFY9zmG3xOkrEaXDAyD9hCmpGgrKGs3dRFujsLyx5QiWPUc3ajjQVGiZuCqV6_A1QxczVHeskRXpw7TboTur-1EuAg-HQUFCOwdRJWMA2-gc7FAV11w_-_x8Z8SZnDeGT08wQFSH6boC0VFVWKKqB_z2OepE1ncouH8D6AVq3g</recordid><startdate>20081115</startdate><enddate>20081115</enddate><creator>Yasuda, Y</creator><creator>Shimoda, T</creator><creator>Uno, K</creator><creator>Tateishi, N</creator><creator>Furuya, S</creator><creator>Yagi, K</creator><creator>Suzuki, K</creator><creator>Fujita, S</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20081115</creationdate><title>The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains</title><author>Yasuda, Y ; Shimoda, T ; Uno, K ; Tateishi, N ; Furuya, S ; Yagi, K ; Suzuki, K ; Fujita, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-223fcc7501d2f8726152033fa101aacaf0355499a802b837e57f8e1b41e7a98b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology</topic><topic>Allergy and Immunology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Astrocytes - drug effects</topic><topic>Chemokine</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Cytokine</topic><topic>Cytokines - blood</topic><topic>Cytokines - cerebrospinal fluid</topic><topic>Drug Administration Schedule</topic><topic>Glia</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Microglia - drug effects</topic><topic>Movement - drug effects</topic><topic>MPTP sensitivity</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Neurology</topic><topic>Neurotoxins - pharmacology</topic><topic>S100 Calcium Binding Protein beta Subunit</topic><topic>S100 Proteins - metabolism</topic><topic>Species Specificity</topic><topic>Strain difference</topic><topic>Time Factors</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasuda, Y</creatorcontrib><creatorcontrib>Shimoda, T</creatorcontrib><creatorcontrib>Uno, K</creatorcontrib><creatorcontrib>Tateishi, N</creatorcontrib><creatorcontrib>Furuya, S</creatorcontrib><creatorcontrib>Yagi, K</creatorcontrib><creatorcontrib>Suzuki, K</creatorcontrib><creatorcontrib>Fujita, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasuda, Y</au><au>Shimoda, T</au><au>Uno, K</au><au>Tateishi, N</au><au>Furuya, S</au><au>Yagi, K</au><au>Suzuki, K</au><au>Fujita, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2008-11-15</date><risdate>2008</risdate><volume>204</volume><issue>1</issue><spage>43</spage><epage>51</epage><pages>43-51</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-γ, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>18817984</pmid><doi>10.1016/j.jneuroim.2008.08.003</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 2008-11, Vol.204 (1), p.43-51 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19512964 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Allergy and Immunology Analysis of Variance Animals Astrocytes - drug effects Chemokine Corpus Striatum - drug effects Corpus Striatum - metabolism Cytokine Cytokines - blood Cytokines - cerebrospinal fluid Drug Administration Schedule Glia Male Mice Mice, Inbred Strains Microglia - drug effects Movement - drug effects MPTP sensitivity Nerve Growth Factors - metabolism Neurology Neurotoxins - pharmacology S100 Calcium Binding Protein beta Subunit S100 Proteins - metabolism Species Specificity Strain difference Time Factors Tyrosine 3-Monooxygenase - metabolism |
| title | The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T23%3A34%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20MPTP%20on%20the%20activation%20of%20microglia/astrocytes%20and%20cytokine/chemokine%20levels%20in%20different%20mice%20strains&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Yasuda,%20Y&rft.date=2008-11-15&rft.volume=204&rft.issue=1&rft.spage=43&rft.epage=51&rft.pages=43-51&rft.issn=0165-5728&rft.eissn=1872-8421&rft_id=info:doi/10.1016/j.jneuroim.2008.08.003&rft_dat=%3Cproquest_cross%3E19512964%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19512964&rft_id=info:pmid/18817984&rft_els_id=S0165572808003573&rfr_iscdi=true |