Morphological Change Caused by Loss of the Taxon-Specific Polyalanine Tract in Hoxd-13
Sequence comparison of Hoxd-13 among vertebrates revealed the presence of taxon-specific polyalanine tracts in amniotes. To investigate their function at the organismal level, we replaced the wild-type Hoxd-13 gene with one lacking the 15-residue polyalanine tract by using homologous recombination....
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| Veröffentlicht in: | Molecular biology and evolution 2007-01, Vol.24 (1), p.281-287 |
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| container_title | Molecular biology and evolution |
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| creator | Anan, Keiiti Yoshida, Nobuaki Kataoka, Yuki Sato, Mitsuharu Ichise, Hirotake Nasu, Makoto Ueda, Shintaroh |
| description | Sequence comparison of Hoxd-13 among vertebrates revealed the presence of taxon-specific polyalanine tracts in amniotes. To investigate their function at the organismal level, we replaced the wild-type Hoxd-13 gene with one lacking the 15-residue polyalanine tract by using homologous recombination. Sesamoid bone formation in knock-in mice was different from that in the wild type; this was observed not only in the homozygotes but also in the heterozygotes. The present study provides the first direct evidence that taxon-specific homopolymeric amino acid repeats are involved in phenotypic diversification at the organismal level. |
| doi_str_mv | 10.1093/molbev/msl161 |
| format | Article |
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To investigate their function at the organismal level, we replaced the wild-type Hoxd-13 gene with one lacking the 15-residue polyalanine tract by using homologous recombination. Sesamoid bone formation in knock-in mice was different from that in the wild type; this was observed not only in the homozygotes but also in the heterozygotes. The present study provides the first direct evidence that taxon-specific homopolymeric amino acid repeats are involved in phenotypic diversification at the organismal level.</description><identifier>ISSN: 0737-4038</identifier><identifier>EISSN: 1537-1719</identifier><identifier>DOI: 10.1093/molbev/msl161</identifier><identifier>PMID: 17065594</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Amino Acid Sequence ; Amino acids ; Amniota ; Animals ; Bone and Bones - anatomy & histology ; Evolution, Molecular ; Extremities - anatomy & histology ; Homeodomain Proteins - chemistry ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Mice ; Molecular Sequence Data ; Mutagenesis ; Peptides - metabolism ; Recombination, Genetic ; Sequence Alignment ; Transcription Factors - chemistry ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Molecular biology and evolution, 2007-01, Vol.24 (1), p.281-287</ispartof><rights>The Author 2006. 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| issn | 0737-4038 1537-1719 |
| language | eng |
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| source | Oxford Journals Open Access Collection |
| subjects | Amino Acid Sequence Amino acids Amniota Animals Bone and Bones - anatomy & histology Evolution, Molecular Extremities - anatomy & histology Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Mice Molecular Sequence Data Mutagenesis Peptides - metabolism Recombination, Genetic Sequence Alignment Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism |
| title | Morphological Change Caused by Loss of the Taxon-Specific Polyalanine Tract in Hoxd-13 |
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