Novel selective PPARδ agonists: Optimization of activity by modification of alkynylallylic moiety

Selective PPARδ agonists, 6, were obtained by SAR study of structural changes of the PPARpan agonist 5. Y-shaped molecules bearing alkynylallylic moieties were found to be potent and selective PPARδ activators. The alkynylallylic moiety was synthesized from alkyn-1-ols by hydroalumination followed b...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-08, Vol.17 (15), p.4144-4149
Hauptverfasser:	Havranek, Miroslav, Sauerberg, Per, Mogensen, John P., Kratina, Pavel, Jeppesen, Claus B., Pettersson, Ingrid, Pihera, Pavel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Hydroalumination Medical sciences Miscellaneous Nuclear receptor Peroxisome proliferator-activated receptor δ Pharmacology. Drug treatments PPAR agonists Substituted allyl alcohols
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