Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys

Human butyrylcholinesterase (HuBuChE), purified from outdated human plasma, is being evaluated for efficacy against nerve agents in guinea pigs and cynomolgus monkeys. Previous studies in rodents and nonhuman primates demonstrated that pretreatment of animals with enzymes that can scavenge nerve age...

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Veröffentlicht in:	Chemico-biological interactions 2005-12, Vol.157 (C (Special Issue)), p.205-210
Hauptverfasser:	Lenz, David E., Maxwell, Donald M., Koplovitz, Irwin, Clark, Connie R., Capacio, Benjamin R., Cerasoli, Douglas M., Federko, James M., Luo, Chunyuan, Saxena, Ashima, Doctor, Bhupendra P., Olson, Carl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Butyrylcholinesterase Butyrylcholinesterase - administration & dosage Butyrylcholinesterase - pharmacokinetics Butyrylcholinesterase - pharmacology Cynomolgus Cynomolgus monkey Guinea Pigs Humans Lethal Dose 50 Macaca fascicularis - metabolism Male Nervous System Diseases - prevention & control Organothiophosphorus Compounds - antagonists & inhibitors Organothiophosphorus Compounds - poisoning Primates Soman
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