toxicity study of low-dose rate half-body irradiation and chemotherapy in dogs with lymphoma
Thirteen dogs with previously untreated multicentric lymphoma were enrolled in a prospective study investigating the effects of low-dose rate total body irradiation (TBI) and chemotherapy. Dogs received either 6 or 8 Gy TBI in half-body fractions, 2 weeks apart. Toxicity consisted of mild to moderat...
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| Veröffentlicht in: | Veterinary & comparative oncology 2008-12, Vol.6 (4), p.257-267 |
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| creator | Lurie, D.M Kent, M.S Fry, M.M Théon, A.P |
| description | Thirteen dogs with previously untreated multicentric lymphoma were enrolled in a prospective study investigating the effects of low-dose rate total body irradiation (TBI) and chemotherapy. Dogs received either 6 or 8 Gy TBI in half-body fractions, 2 weeks apart. Toxicity consisted of mild to moderate haematological and gastrointestinal (GI) signs. One dog died from treatment complications. Anorexia was noted independent of dose. Haematological toxicity was more common and more severe after 8 Gy treatment. GI toxicity was more likely postcaudal half-body irradiation with 8 Gy. Other than leukotrichia, late effects from radiation were not observed. Results indicated that haematological and nonhaematological toxicity was dose dependent. However, the protocol was well tolerated and treatment intensification using a 2-week inter-radiation interval was possible in all dogs treated with 6 Gy. Preliminary survival data for these dogs were very encouraging, providing a strong rationale to analyse the efficacy of low-dose rate irradiation (LDRI) in canine lymphoma. |
| doi_str_mv | 10.1111/j.1476-5829.2008.00164.x |
| format | Article |
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Dogs received either 6 or 8 Gy TBI in half-body fractions, 2 weeks apart. Toxicity consisted of mild to moderate haematological and gastrointestinal (GI) signs. One dog died from treatment complications. Anorexia was noted independent of dose. Haematological toxicity was more common and more severe after 8 Gy treatment. GI toxicity was more likely postcaudal half-body irradiation with 8 Gy. Other than leukotrichia, late effects from radiation were not observed. Results indicated that haematological and nonhaematological toxicity was dose dependent. However, the protocol was well tolerated and treatment intensification using a 2-week inter-radiation interval was possible in all dogs treated with 6 Gy. 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Dogs received either 6 or 8 Gy TBI in half-body fractions, 2 weeks apart. Toxicity consisted of mild to moderate haematological and gastrointestinal (GI) signs. One dog died from treatment complications. Anorexia was noted independent of dose. Haematological toxicity was more common and more severe after 8 Gy treatment. GI toxicity was more likely postcaudal half-body irradiation with 8 Gy. Other than leukotrichia, late effects from radiation were not observed. Results indicated that haematological and nonhaematological toxicity was dose dependent. However, the protocol was well tolerated and treatment intensification using a 2-week inter-radiation interval was possible in all dogs treated with 6 Gy. Preliminary survival data for these dogs were very encouraging, providing a strong rationale to analyse the efficacy of low-dose rate irradiation (LDRI) in canine lymphoma.</description><subject>adverse effects</subject><subject>Animals</subject><subject>antineoplastic agents</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>blood</subject><subject>bone marrow</subject><subject>chemotherapy</subject><subject>dog diseases</subject><subject>Dog Diseases - drug therapy</subject><subject>Dog Diseases - radiotherapy</subject><subject>Dogs</subject><subject>dosage</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>drug toxicity</subject><subject>Female</subject><subject>gastrointestinal</subject><subject>gastrointestinal system</subject><subject>Hemibody Irradiation - adverse effects</subject><subject>Hemibody Irradiation - veterinary</subject><subject>irradiation</subject><subject>lymphoma</subject><subject>Lymphoma - drug therapy</subject><subject>Lymphoma - radiotherapy</subject><subject>Lymphoma - veterinary</subject><subject>Male</subject><subject>mortality</subject><subject>Radiation Injuries</subject><subject>radiotherapy</subject><subject>toxicity</subject><subject>wide-field irradiation</subject><issn>1476-5810</issn><issn>1476-5829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v0zAUhi0EYmPwF8BX3CXzsZ0viRtUbYVp2jSNMYSQrNPYWVySutip2vx73KUqt_jGR3qf99h6CKHAUojnfJmCLPIkK3mVcsbKlDHIZbp7QU6PwcvjDOyEvAlhyRjnUvDX5AQqKMq8lKfk1-B2trbDSMOw0SN1De3cNtEuGOpxMLTFrkkWLkbWe9QWB-tWFFea1q3p3dAaj-sYrqh2T4Fu7dDSbuzXrevxLXnVYBfMu8N9Rh4uL77NviTXt_Ovs8_XSS2zSiZllTPkZS1A54WsMgZVoStpaq01lBwxK7VYMIESUGaRKeLnOQcJNdYoUJyRj9PetXd_NiYMqrehNl2HK-M2QUHcmRUCIlhOYO1dCN40au1tj35UwNTerFqqvTS1F6j2ZtWzWbWL1feHNzaL3uh_xYPKCHyagK3tzPjfi9X32W0cYj2Z6jYMZneso_-t8kIUmXq8mav53SPkP69-qMvIf5j4Bp3CJ2-DerjnDASDLIc84-IvC_efwQ</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Lurie, D.M</creator><creator>Kent, M.S</creator><creator>Fry, M.M</creator><creator>Théon, A.P</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>200812</creationdate><title>toxicity study of low-dose rate half-body irradiation and chemotherapy in dogs with lymphoma</title><author>Lurie, D.M ; Kent, M.S ; Fry, M.M ; Théon, A.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4594-8960a28c31d674950197d94ecddd182aa58d3b03a41a45d67778622141caca3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>adverse effects</topic><topic>Animals</topic><topic>antineoplastic agents</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>blood</topic><topic>bone marrow</topic><topic>chemotherapy</topic><topic>dog diseases</topic><topic>Dog Diseases - drug therapy</topic><topic>Dog Diseases - radiotherapy</topic><topic>Dogs</topic><topic>dosage</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>drug toxicity</topic><topic>Female</topic><topic>gastrointestinal</topic><topic>gastrointestinal system</topic><topic>Hemibody Irradiation - adverse effects</topic><topic>Hemibody Irradiation - veterinary</topic><topic>irradiation</topic><topic>lymphoma</topic><topic>Lymphoma - drug therapy</topic><topic>Lymphoma - radiotherapy</topic><topic>Lymphoma - veterinary</topic><topic>Male</topic><topic>mortality</topic><topic>Radiation Injuries</topic><topic>radiotherapy</topic><topic>toxicity</topic><topic>wide-field irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lurie, D.M</creatorcontrib><creatorcontrib>Kent, M.S</creatorcontrib><creatorcontrib>Fry, M.M</creatorcontrib><creatorcontrib>Théon, A.P</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Veterinary & comparative oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lurie, D.M</au><au>Kent, M.S</au><au>Fry, M.M</au><au>Théon, A.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>toxicity study of low-dose rate half-body irradiation and chemotherapy in dogs with lymphoma</atitle><jtitle>Veterinary & comparative oncology</jtitle><addtitle>Vet Comp Oncol</addtitle><date>2008-12</date><risdate>2008</risdate><volume>6</volume><issue>4</issue><spage>257</spage><epage>267</epage><pages>257-267</pages><issn>1476-5810</issn><eissn>1476-5829</eissn><abstract>Thirteen dogs with previously untreated multicentric lymphoma were enrolled in a prospective study investigating the effects of low-dose rate total body irradiation (TBI) and chemotherapy. Dogs received either 6 or 8 Gy TBI in half-body fractions, 2 weeks apart. Toxicity consisted of mild to moderate haematological and gastrointestinal (GI) signs. One dog died from treatment complications. Anorexia was noted independent of dose. Haematological toxicity was more common and more severe after 8 Gy treatment. GI toxicity was more likely postcaudal half-body irradiation with 8 Gy. Other than leukotrichia, late effects from radiation were not observed. Results indicated that haematological and nonhaematological toxicity was dose dependent. However, the protocol was well tolerated and treatment intensification using a 2-week inter-radiation interval was possible in all dogs treated with 6 Gy. Preliminary survival data for these dogs were very encouraging, providing a strong rationale to analyse the efficacy of low-dose rate irradiation (LDRI) in canine lymphoma.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>19178684</pmid><doi>10.1111/j.1476-5829.2008.00164.x</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | adverse effects Animals antineoplastic agents Antineoplastic Agents - therapeutic use blood bone marrow chemotherapy dog diseases Dog Diseases - drug therapy Dog Diseases - radiotherapy Dogs dosage Dose-Response Relationship, Immunologic drug toxicity Female gastrointestinal gastrointestinal system Hemibody Irradiation - adverse effects Hemibody Irradiation - veterinary irradiation lymphoma Lymphoma - drug therapy Lymphoma - radiotherapy Lymphoma - veterinary Male mortality Radiation Injuries radiotherapy toxicity wide-field irradiation |
| title | toxicity study of low-dose rate half-body irradiation and chemotherapy in dogs with lymphoma |
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