Monitoring Bone Tissue Engineered (BTE) Constructs Based on the Shifting Metabolism of Differentiating Stem Cells

Ever-increasing demand for bone grafts necessitates the realization of clinical implementation of bone tissue engineered constructs. The predominant hurdle to implementation remains to be securing FDA approval, based on the lack of viable methods for the rigorous monitoring of said constructs. The s...

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Veröffentlicht in:	Annals of biomedical engineering 2018, Vol.46 (1), p.37-47
Hauptverfasser:	Simmons, Aaron D., Sikavitsas, Vassilios I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biocompatibility Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedical materials Biomedicine Biophysics Bioreactors Bone and Bones - metabolism Bone grafts Bones Cell culture Cells, Cultured Classical Mechanics Construction engineering Culture Media - analysis FDA approval Glucose Glucose - metabolism Grafts Male Maturation Mesenchymal Stem Cells - metabolism Mesenchyme Metabolism Mineralization Monitoring Osteoblastogenesis Osteoblasts Osteocalcin Osteocalcin - metabolism Osteogenesis Osteoprotegerin Osteoprotegerin - metabolism Oxygen Consumption Oxygen uptake Perfusion Polylactic acid Rats, Wistar Regulatory agencies Scaffolds Stem cell transplantation Stem cells Tissue Engineering Tissue Scaffolds
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