Formamidopyrimidines in DNA: Mechanisms of formation, repair, and biological effects

Oxidatively induced damage to DNA results in a plethora of lesions comprising modified bases and sugars, DNA–protein cross-links, tandem lesions, strand breaks, and clustered lesions. Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (F...

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Veröffentlicht in:	Free radical biology & medicine 2008-12, Vol.45 (12), p.1610-1621
Hauptverfasser:	Dizdaroglu, Miral, Kirkali, Güldal, Jaruga, Pawel
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - metabolism DNA Repair DNA-Formamidopyrimidine Glycosylase - metabolism Formamidopyrimidines Free radicals Humans Mutagenesis NEIL1 OH-adduct radicals Pyrimidines - metabolism
Online-Zugang:	Volltext
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