Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China
Sporothrix globosa is the main causative agent of sporotrichosis, a common mycosis that usually affects the skin, in China. Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study...
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| Veröffentlicht in: | Emerging microbes & infections 2017-10, Vol.6 (1), p.1-13 |
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| creator | Zhao, Lipei Cui, Yan Zhen, Yu Yao, Lei Shi, Ying Song, Yang Chen, Ruili Li, Shanshan |
| description | Sporothrix globosa is the main causative agent of sporotrichosis, a common mycosis that usually affects the skin, in China. Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study were to assess the genetic diversity of S. globosa using amplified fragment length polymorphism (AFLP) analysis and to assess the correlation of AFLP profiles with the geographic origins, growth rates, clinical forms, and antifungal susceptibilities of S. globosa isolates. AFLP analysis of 225 clinical S. globosa isolates from eight provinces or municipalities in China identified eight distinct clustering groups (I-VIII), with groups I, II and IV being the most common. The AFLP genotypes showed distinct distribution patterns among different regions within Jilin Province and between northern and southern China, but there was no obvious association between the AFLP genotypes and the growth rates, clinical forms or antifungal susceptibilities of the S. globosa isolates. These results expand our understanding of the genetic variation of S. globosa and suggest that AFLP analysis is a potentially useful tool for studying the epidemiology of this fungal pathogen.
Emerging Microbes & Infections (2017) 6, e88; doi:
10.1038/emi.2017.75
; published online 11 October 2017 |
| doi_str_mv | 10.1038/emi.2017.75 |
| format | Article |
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Emerging Microbes & Infections (2017) 6, e88; doi:
10.1038/emi.2017.75
; published online 11 October 2017</description><identifier>ISSN: 2222-1751</identifier><identifier>EISSN: 2222-1751</identifier><identifier>DOI: 10.1038/emi.2017.75</identifier><identifier>PMID: 29018254</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Adolescent ; Adult ; Aged ; amplified fragment length polymorphism ; Antifungal Agents - pharmacology ; Child ; Child, Preschool ; China ; Epidemiology ; Female ; Genetic Variation ; Genotype & phenotype ; genotyping ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Original ; Pathogens ; Polymorphism, Genetic ; Sporothrix - drug effects ; Sporothrix - genetics ; Sporothrix - isolation & purification ; Sporothrix globosa ; sporotrichosis ; Sporotrichosis - microbiology</subject><ispartof>Emerging microbes & infections, 2017-10, Vol.6 (1), p.1-13</ispartof><rights>The Author(s) 2017 2017</rights><rights>Copyright Nature Publishing Group Oct 2017</rights><rights>The Author(s) 2017. This work is licensed under the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2017 The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-8e4ad4b322bb3331b30287fa3b2fd4e6d2b191b149780d2423bff58b0c3b9fa03</citedby><cites>FETCH-LOGICAL-c550t-8e4ad4b322bb3331b30287fa3b2fd4e6d2b191b149780d2423bff58b0c3b9fa03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658771/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658771/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27502,27924,27925,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29018254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Lipei</creatorcontrib><creatorcontrib>Cui, Yan</creatorcontrib><creatorcontrib>Zhen, Yu</creatorcontrib><creatorcontrib>Yao, Lei</creatorcontrib><creatorcontrib>Shi, Ying</creatorcontrib><creatorcontrib>Song, Yang</creatorcontrib><creatorcontrib>Chen, Ruili</creatorcontrib><creatorcontrib>Li, Shanshan</creatorcontrib><title>Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China</title><title>Emerging microbes & infections</title><addtitle>Emerg Microbes Infect</addtitle><description>Sporothrix globosa is the main causative agent of sporotrichosis, a common mycosis that usually affects the skin, in China. Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study were to assess the genetic diversity of S. globosa using amplified fragment length polymorphism (AFLP) analysis and to assess the correlation of AFLP profiles with the geographic origins, growth rates, clinical forms, and antifungal susceptibilities of S. globosa isolates. AFLP analysis of 225 clinical S. globosa isolates from eight provinces or municipalities in China identified eight distinct clustering groups (I-VIII), with groups I, II and IV being the most common. The AFLP genotypes showed distinct distribution patterns among different regions within Jilin Province and between northern and southern China, but there was no obvious association between the AFLP genotypes and the growth rates, clinical forms or antifungal susceptibilities of the S. globosa isolates. These results expand our understanding of the genetic variation of S. globosa and suggest that AFLP analysis is a potentially useful tool for studying the epidemiology of this fungal pathogen.
Emerging Microbes & Infections (2017) 6, e88; doi:
10.1038/emi.2017.75
; published online 11 October 2017</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>amplified fragment length polymorphism</subject><subject>Antifungal Agents - pharmacology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Genotype & phenotype</subject><subject>genotyping</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Pathogens</subject><subject>Polymorphism, Genetic</subject><subject>Sporothrix - drug effects</subject><subject>Sporothrix - genetics</subject><subject>Sporothrix - isolation & purification</subject><subject>Sporothrix globosa</subject><subject>sporotrichosis</subject><subject>Sporotrichosis - microbiology</subject><issn>2222-1751</issn><issn>2222-1751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks1rFDEYhwdRbKk9eZeAF0F2zeckuQiy2FooeFDPIZkks1kyyZrMbu1_b7ZbSyvie0lIHh7y5v113WsElwgS8cFNYYkh4kvOnnWnuNUCcYaeP9qfdOe1bmArDnuK6MvuBEuIBGb0tPOXLrk5DGCvS9BzyAlkD75tc8nzuoRfYIzZ5KpBqDnq2VXgS56ADXtXqgOjy2PR23UT6GTBEEMKg44glzCGVEFIYLUOSb_qXngdqzu_X8-6Hxefv6--LK6_Xl6tPl0vBsbgvBCOaksNwdgYQggyBGLBvSYGe0tdb7FBEhlEJRfQYoqJ8Z4JAwdipNeQnHVXR6_NeqO2JUy63Kqsg7o7yGVUurR2o1NEQkokgs2PaE-FNFYaZhm2EBEoSXN9PLq2OzM5O7g0Fx2fSJ_epLBWY94r1jPBOWqCd_eCkn_uXJ3VFOrgYtTJ5V1VSLLDGJCQDX37F7rJu5LaVynMUM_bLAn-H4UklUwgTkWj3h-poeRai_MPT0ZQHUKjWmjUITSKs0a_edzlA_snIg3oj0BIPpdJ3-QSrZr1bczFF52GUBX5l_k3rC7OkQ</recordid><startdate>20171011</startdate><enddate>20171011</enddate><creator>Zhao, Lipei</creator><creator>Cui, Yan</creator><creator>Zhen, Yu</creator><creator>Yao, Lei</creator><creator>Shi, Ying</creator><creator>Song, Yang</creator><creator>Chen, Ruili</creator><creator>Li, Shanshan</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Nature Publishing Group</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20171011</creationdate><title>Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China</title><author>Zhao, Lipei ; 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Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study were to assess the genetic diversity of S. globosa using amplified fragment length polymorphism (AFLP) analysis and to assess the correlation of AFLP profiles with the geographic origins, growth rates, clinical forms, and antifungal susceptibilities of S. globosa isolates. AFLP analysis of 225 clinical S. globosa isolates from eight provinces or municipalities in China identified eight distinct clustering groups (I-VIII), with groups I, II and IV being the most common. The AFLP genotypes showed distinct distribution patterns among different regions within Jilin Province and between northern and southern China, but there was no obvious association between the AFLP genotypes and the growth rates, clinical forms or antifungal susceptibilities of the S. globosa isolates. These results expand our understanding of the genetic variation of S. globosa and suggest that AFLP analysis is a potentially useful tool for studying the epidemiology of this fungal pathogen.
Emerging Microbes & Infections (2017) 6, e88; doi:
10.1038/emi.2017.75
; published online 11 October 2017</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>29018254</pmid><doi>10.1038/emi.2017.75</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged amplified fragment length polymorphism Antifungal Agents - pharmacology Child Child, Preschool China Epidemiology Female Genetic Variation Genotype & phenotype genotyping Humans Infant Male Microbial Sensitivity Tests Middle Aged Original Pathogens Polymorphism, Genetic Sporothrix - drug effects Sporothrix - genetics Sporothrix - isolation & purification Sporothrix globosa sporotrichosis Sporotrichosis - microbiology |
| title | Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China |
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