The calcineurin‐NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection

The calcineurin‐NFAT axis contributes to host response to Pseudomonas aeruginosa lung infection. Infection with the opportunistic pathogen Pseudomonas aeruginosa is effectively controlled through tightly coordinated inflammation in healthy individuals. Dysregulated inflammation in cystic fibrosis gr...

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Veröffentlicht in:	Journal of leukocyte biology 2017-12, Vol.102 (6), p.1461-1469
Hauptverfasser:	Pang, Zheng, Junkins, Robert D., MacNeil, Adam J., McCormick, Craig, Cheng, Zhenyu, Chen, Wei‐Min, Lin, Tong‐Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcineurin Calcineurin - metabolism Calcium Calcium-binding protein Calmodulin Cystic fibrosis Cytokines - biosynthesis Damage detection Female I-kappa B Kinase - metabolism Infections Inflammation Inflammation Mediators - metabolism Inflammatory response Lung - microbiology Lung - pathology Lungs macrophage Macrophages - metabolism Macrophages - pathology Male Mice NF-AT protein NF-kappa B - metabolism NFATC Transcription Factors - metabolism NFкB Nuclear transport Opportunist infection Pathogens phosphatase Promoter Regions, Genetic - genetics Protein Binding Pseudomonas aeruginosa Pseudomonas aeruginosa - physiology Pseudomonas Infections - metabolism Pseudomonas Infections - microbiology Pseudomonas Infections - pathology Respiratory Tract Infections - metabolism Respiratory Tract Infections - microbiology Respiratory Tract Infections - pathology Signal Transduction Transcription factors Transcription, Genetic Translocation
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