Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway

The aim of present study is to explore the cytoprotection of curcumin against 1-methyl-4-phenylpridinium ions (MPP(+))-induced apoptosis and the molecular mechanisms underlying in PC12 cells. Our findings indicated that MPP(+) significantly reduced the cell viability and induced apoptosis of PC12 ce...

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Veröffentlicht in:	Apoptosis (London) 2006-06, Vol.11 (6), p.943-953
Hauptverfasser:	Chen, J, Tang, X Q, Zhi, J L, Cui, Y, Yu, H M, Tang, E H, Sun, S N, Feng, J Q, Chen, P X
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - pharmacology Animals Apoptosis Apoptosis - drug effects Cells Curcumin - pharmacology Cytotoxicity Enzyme Inhibitors - pharmacology Herbicides - pharmacology Mitochondria - drug effects Nitric oxide Nitric Oxide Synthase Type II - physiology Oxidative stress Parkinson Disease - drug therapy Parkinson's disease Proto-Oncogene Proteins c-bcl-2 - physiology Rats Reactive Oxygen Species - metabolism
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