Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging

Cellular senescence (CS) is underlying mechanism of organism aging and is closely interconnected with age-related diseases (ARDs). Thus, any attempt that influences CS, may be undertaken to reverse or inhibit senescence, whereby could prolong healthy life span. Until now, two main proposes are epige...

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Veröffentlicht in:	Ageing research reviews 2017-11, Vol.40, p.120-141
Hauptverfasser:	Hekmatimoghaddam, Seyedhossein, Dehghani Firoozabadi, Ali, Zare-Khormizi, Mohamad Reza, Pourrajab, Fatemeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Animals Cell Differentiation - physiology Cellular Senescence - physiology Epigenesis, Genetic - physiology Humans MicroRNAs - genetics MicroRNAs - metabolism Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Signal Transduction - physiology Sirtuin 1 - genetics Sirtuin 1 - metabolism
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