Protein Kinase C-induced Activation of a Ceramide/Protein Phosphatase 1 Pathway Leading to Dephosphorylation of p38 MAPK

Recently we showed that, in human breast cancer cells, activation of protein kinase C by 4β-phorbol 12-myristate 13-acetate (PMA) produced ceramide formed from the salvage pathway (Becker, K. P., Kitatani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y. A. (2005) J. Biol. Chem. 280, 2606-2612...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2006-12, Vol.281 (48), p.36793-36802
Hauptverfasser:	Kitatani, Kazuyuki, Idkowiak-Baldys, Jolanta, Bielawski, Jacek, Taha, Tarek A., Jenkins, Russell W., Senkal, Can E., Ogretmen, Besim, Obeid, Lina M., Hannun, Yusuf A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain Cell Line, Tumor Enzyme Activation Gene Expression Regulation, Neoplastic Humans Mitochondria - metabolism Models, Biological p38 Mitogen-Activated Protein Kinases - metabolism Phosphoprotein Phosphatases - chemistry Phosphorylation Protein Kinase C - metabolism Protein Phosphatase 1 RNA, Small Interfering - metabolism Signal Transduction Subcellular Fractions Tetradecanoylphorbol Acetate - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!