Omalizumab for severe chronic spontaneous urticaria: Real-life experiences of 280 patients
Chronic spontaneous urticaria (CSU) is a debilitating disorder.[...]well-defined therapeutic strategies are required to achieve a maximal remission and maintain quality of life.The first involves highly cytokinergic monomeric IgEs, which by binding Fc region of immunoglobulin E receptor I (FcɛRI) in...
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creator | Vadasz, Zahava Tal, Yuval Rotem, Menachem Shichter-Confino, Vered Mahlab-Guri, Keren Graif, Yael Kessel, Aharon Agmon-Levin, Nancy Maoz-Segal, Ramit Kivity, Shmuel Benor, Shira Lachover-Roth, Idit Zeldin, Yuri Stein, Migel Toker, Ori Hassoun, Gamal Bezalel-Rosenberg, Shira Toubi, Elias Asher, Ilan Sthoeger, Zev |
description | Chronic spontaneous urticaria (CSU) is a debilitating disorder.[...]well-defined therapeutic strategies are required to achieve a maximal remission and maintain quality of life.The first involves highly cytokinergic monomeric IgEs, which by binding Fc region of immunoglobulin E receptor I (FcɛRI) in the absence of antigens induce mast cell activation and histamine release.6 The second is the binding of autoreactive antibodies on activated skin mast cells.[...]we suggest that the fast onset of response to omalizumab could be explained by the rapid sequestration of monomeric-free IgEs and the silencing of mast cell degranulation.Hsieh, S. Saini, C. Grattan, A. Gimenez-Arnau, Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria, N Engl J Med, Vol. 368, 2013, 924-935 4 T. Zuberbier, W. Aberer, R. Asero, C. Bindslev-Jensen, Z. Brzoza, G.W. Canonica, 2, Allergy, Vol. 69, 2014, 868-887 5 M. Metz, T. Ohanyan, M.K. Church, M. Maurer, Omalizumab is an effective and rapidly acting therapy in difficult-to-treat chronic urticaria: a retrospective clinical analysis, J Dermato Sci, Vol. 73, 2013, 57-62 6 J. Kashiwakura, Y. Okayama, M. Furue, K. Kabashima, S. Shimada, C. Ra, Most highly cytokinergic IgEs have polyreactivity to autoantigens, Allergy Asthma Immunol Res, Vol. 4, 2012, 332-340 7 T.W. Chang, C. Chen, C.J. Lin, M. Metz, M.K. Church, M. Maurer, The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria, J Allergy Clin Immunol, Vol. 135, 2015, 337-342 8 A.P. Kaplan, A.M. Gimenez-Arnau, S.S. Saini, Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria, Allergy, Vol. 72, 2017, 519-533 9 M. Maurer, S. Altrichter, T. Bieber, T. Biedermann, M. Brautigam, S. Seyfried, Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase, J Allergy Clin Immunol, Vol. 128, 2011, 202-209.e5 |
doi_str_mv | 10.1016/j.jaip.2017.08.035 |
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Saini, C. Grattan, A. Gimenez-Arnau, Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria, N Engl J Med, Vol. 368, 2013, 924-935 4 T. Zuberbier, W. Aberer, R. Asero, C. Bindslev-Jensen, Z. Brzoza, G.W. Canonica, 2, Allergy, Vol. 69, 2014, 868-887 5 M. Metz, T. Ohanyan, M.K. Church, M. Maurer, Omalizumab is an effective and rapidly acting therapy in difficult-to-treat chronic urticaria: a retrospective clinical analysis, J Dermato Sci, Vol. 73, 2013, 57-62 6 J. Kashiwakura, Y. Okayama, M. Furue, K. Kabashima, S. Shimada, C. Ra, Most highly cytokinergic IgEs have polyreactivity to autoantigens, Allergy Asthma Immunol Res, Vol. 4, 2012, 332-340 7 T.W. Chang, C. Chen, C.J. Lin, M. Metz, M.K. Church, M. Maurer, The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria, J Allergy Clin Immunol, Vol. 135, 2015, 337-342 8 A.P. Kaplan, A.M. Gimenez-Arnau, S.S. Saini, Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria, Allergy, Vol. 72, 2017, 519-533 9 M. Maurer, S. Altrichter, T. Bieber, T. Biedermann, M. Brautigam, S. Seyfried, Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase, J Allergy Clin Immunol, Vol. 128, 2011, 202-209.e5</description><identifier>ISSN: 2213-2198</identifier><identifier>EISSN: 2213-2201</identifier><identifier>DOI: 10.1016/j.jaip.2017.08.035</identifier><identifier>PMID: 28988786</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Dermatitis ; Drug dosages ; Drug therapy ; Immunoglobulin E ; Immunotherapy ; Monoclonal antibodies ; Urticaria</subject><ispartof>The journal of allergy and clinical immunology in practice (Cambridge, MA), 2017-11, Vol.5 (6), p.1743-1745</ispartof><rights>2017 American Academy of Allergy, Asthma & Immunology</rights><rights>2017. 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Saini, C. Grattan, A. Gimenez-Arnau, Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria, N Engl J Med, Vol. 368, 2013, 924-935 4 T. Zuberbier, W. Aberer, R. Asero, C. Bindslev-Jensen, Z. Brzoza, G.W. Canonica, 2, Allergy, Vol. 69, 2014, 868-887 5 M. Metz, T. Ohanyan, M.K. Church, M. Maurer, Omalizumab is an effective and rapidly acting therapy in difficult-to-treat chronic urticaria: a retrospective clinical analysis, J Dermato Sci, Vol. 73, 2013, 57-62 6 J. Kashiwakura, Y. Okayama, M. Furue, K. Kabashima, S. Shimada, C. Ra, Most highly cytokinergic IgEs have polyreactivity to autoantigens, Allergy Asthma Immunol Res, Vol. 4, 2012, 332-340 7 T.W. Chang, C. Chen, C.J. Lin, M. Metz, M.K. Church, M. Maurer, The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria, J Allergy Clin Immunol, Vol. 135, 2015, 337-342 8 A.P. Kaplan, A.M. Gimenez-Arnau, S.S. Saini, Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria, Allergy, Vol. 72, 2017, 519-533 9 M. Maurer, S. Altrichter, T. Bieber, T. Biedermann, M. Brautigam, S. Seyfried, Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase, J Allergy Clin Immunol, Vol. 128, 2011, 202-209.e5</description><subject>Dermatitis</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Immunoglobulin E</subject><subject>Immunotherapy</subject><subject>Monoclonal antibodies</subject><subject>Urticaria</subject><issn>2213-2198</issn><issn>2213-2201</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kM1L5jAQh4MoKq7_gIcl4MVLu_lqO128iOwXCILoxUvIm07YlLbpJq24_vWbd1_1sIedSybDMz-Gh5AzzkrOeP2pL3vj51Iw3pQMSiarPXIsBJeFyLP9t563cEROU-pZLuANU-yQHAloARqoj8nj7WgG_7KOZkNdiDThE0ak9mcMk7c0zWFazIRhTXSNi7cmevOZ3qEZisE7pPg8Y_Q4WUw0OCqA0dksebCkD-TAmSHh6et7Qh6-frm__l7c3H77cX11U1gJailqY5lD5BtplZNKdBKq1kEtO2tRWKxkpzplm_w3G6lMxS1IJsA56RgglyfkYpc7x_BrxbTo0SeLw7C7W_NWtQyapq4zev4P2oc1Tvm6TNWVUqKRkCmxo2wMKUV0eo5-NPG35kxv5eteb-XrrXzNQGf5eenja_S6GbF7X3lTnYHLHYDZxZPHqJP9K67zEe2iu-D_l_8H0iaVoQ</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Vadasz, Zahava</creator><creator>Tal, Yuval</creator><creator>Rotem, Menachem</creator><creator>Shichter-Confino, Vered</creator><creator>Mahlab-Guri, Keren</creator><creator>Graif, Yael</creator><creator>Kessel, Aharon</creator><creator>Agmon-Levin, Nancy</creator><creator>Maoz-Segal, Ramit</creator><creator>Kivity, Shmuel</creator><creator>Benor, Shira</creator><creator>Lachover-Roth, Idit</creator><creator>Zeldin, Yuri</creator><creator>Stein, Migel</creator><creator>Toker, Ori</creator><creator>Hassoun, Gamal</creator><creator>Bezalel-Rosenberg, Shira</creator><creator>Toubi, Elias</creator><creator>Asher, Ilan</creator><creator>Sthoeger, Zev</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Omalizumab for severe chronic spontaneous urticaria: Real-life experiences of 280 patients</title><author>Vadasz, Zahava ; 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Saini, C. Grattan, A. Gimenez-Arnau, Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria, N Engl J Med, Vol. 368, 2013, 924-935 4 T. Zuberbier, W. Aberer, R. Asero, C. Bindslev-Jensen, Z. Brzoza, G.W. Canonica, 2, Allergy, Vol. 69, 2014, 868-887 5 M. Metz, T. Ohanyan, M.K. Church, M. Maurer, Omalizumab is an effective and rapidly acting therapy in difficult-to-treat chronic urticaria: a retrospective clinical analysis, J Dermato Sci, Vol. 73, 2013, 57-62 6 J. Kashiwakura, Y. Okayama, M. Furue, K. Kabashima, S. Shimada, C. Ra, Most highly cytokinergic IgEs have polyreactivity to autoantigens, Allergy Asthma Immunol Res, Vol. 4, 2012, 332-340 7 T.W. Chang, C. Chen, C.J. Lin, M. Metz, M.K. Church, M. Maurer, The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria, J Allergy Clin Immunol, Vol. 135, 2015, 337-342 8 A.P. Kaplan, A.M. Gimenez-Arnau, S.S. 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subjects | Dermatitis Drug dosages Drug therapy Immunoglobulin E Immunotherapy Monoclonal antibodies Urticaria |
title | Omalizumab for severe chronic spontaneous urticaria: Real-life experiences of 280 patients |
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