Omalizumab for severe chronic spontaneous urticaria: Real-life experiences of 280 patients

Chronic spontaneous urticaria (CSU) is a debilitating disorder.[...]well-defined therapeutic strategies are required to achieve a maximal remission and maintain quality of life.The first involves highly cytokinergic monomeric IgEs, which by binding Fc region of immunoglobulin E receptor I (FcɛRI) in...

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Veröffentlicht in:The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2017-11, Vol.5 (6), p.1743-1745
Hauptverfasser: Vadasz, Zahava, Tal, Yuval, Rotem, Menachem, Shichter-Confino, Vered, Mahlab-Guri, Keren, Graif, Yael, Kessel, Aharon, Agmon-Levin, Nancy, Maoz-Segal, Ramit, Kivity, Shmuel, Benor, Shira, Lachover-Roth, Idit, Zeldin, Yuri, Stein, Migel, Toker, Ori, Hassoun, Gamal, Bezalel-Rosenberg, Shira, Toubi, Elias, Asher, Ilan, Sthoeger, Zev
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container_issue 6
container_start_page 1743
container_title The journal of allergy and clinical immunology in practice (Cambridge, MA)
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creator Vadasz, Zahava
Tal, Yuval
Rotem, Menachem
Shichter-Confino, Vered
Mahlab-Guri, Keren
Graif, Yael
Kessel, Aharon
Agmon-Levin, Nancy
Maoz-Segal, Ramit
Kivity, Shmuel
Benor, Shira
Lachover-Roth, Idit
Zeldin, Yuri
Stein, Migel
Toker, Ori
Hassoun, Gamal
Bezalel-Rosenberg, Shira
Toubi, Elias
Asher, Ilan
Sthoeger, Zev
description Chronic spontaneous urticaria (CSU) is a debilitating disorder.[...]well-defined therapeutic strategies are required to achieve a maximal remission and maintain quality of life.The first involves highly cytokinergic monomeric IgEs, which by binding Fc region of immunoglobulin E receptor I (FcɛRI) in the absence of antigens induce mast cell activation and histamine release.6 The second is the binding of autoreactive antibodies on activated skin mast cells.[...]we suggest that the fast onset of response to omalizumab could be explained by the rapid sequestration of monomeric-free IgEs and the silencing of mast cell degranulation.Hsieh, S. Saini, C. Grattan, A. Gimenez-Arnau, Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria, N Engl J Med, Vol. 368, 2013, 924-935 4 T. Zuberbier, W. Aberer, R. Asero, C. Bindslev-Jensen, Z. Brzoza, G.W. Canonica, 2, Allergy, Vol. 69, 2014, 868-887 5 M. Metz, T. Ohanyan, M.K. Church, M. Maurer, Omalizumab is an effective and rapidly acting therapy in difficult-to-treat chronic urticaria: a retrospective clinical analysis, J Dermato Sci, Vol. 73, 2013, 57-62 6 J. Kashiwakura, Y. Okayama, M. Furue, K. Kabashima, S. Shimada, C. Ra, Most highly cytokinergic IgEs have polyreactivity to autoantigens, Allergy Asthma Immunol Res, Vol. 4, 2012, 332-340 7 T.W. Chang, C. Chen, C.J. Lin, M. Metz, M.K. Church, M. Maurer, The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria, J Allergy Clin Immunol, Vol. 135, 2015, 337-342 8 A.P. Kaplan, A.M. Gimenez-Arnau, S.S. Saini, Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria, Allergy, Vol. 72, 2017, 519-533 9 M. Maurer, S. Altrichter, T. Bieber, T. Biedermann, M. Brautigam, S. Seyfried, Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase, J Allergy Clin Immunol, Vol. 128, 2011, 202-209.e5
doi_str_mv 10.1016/j.jaip.2017.08.035
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Saini, C. Grattan, A. Gimenez-Arnau, Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria, N Engl J Med, Vol. 368, 2013, 924-935 4 T. Zuberbier, W. Aberer, R. Asero, C. Bindslev-Jensen, Z. Brzoza, G.W. Canonica, 2, Allergy, Vol. 69, 2014, 868-887 5 M. Metz, T. Ohanyan, M.K. Church, M. Maurer, Omalizumab is an effective and rapidly acting therapy in difficult-to-treat chronic urticaria: a retrospective clinical analysis, J Dermato Sci, Vol. 73, 2013, 57-62 6 J. Kashiwakura, Y. Okayama, M. Furue, K. Kabashima, S. Shimada, C. Ra, Most highly cytokinergic IgEs have polyreactivity to autoantigens, Allergy Asthma Immunol Res, Vol. 4, 2012, 332-340 7 T.W. Chang, C. Chen, C.J. Lin, M. Metz, M.K. Church, M. Maurer, The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria, J Allergy Clin Immunol, Vol. 135, 2015, 337-342 8 A.P. Kaplan, A.M. Gimenez-Arnau, S.S. 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Saini, C. Grattan, A. Gimenez-Arnau, Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria, N Engl J Med, Vol. 368, 2013, 924-935 4 T. Zuberbier, W. Aberer, R. Asero, C. Bindslev-Jensen, Z. Brzoza, G.W. Canonica, 2, Allergy, Vol. 69, 2014, 868-887 5 M. Metz, T. Ohanyan, M.K. Church, M. Maurer, Omalizumab is an effective and rapidly acting therapy in difficult-to-treat chronic urticaria: a retrospective clinical analysis, J Dermato Sci, Vol. 73, 2013, 57-62 6 J. Kashiwakura, Y. Okayama, M. Furue, K. Kabashima, S. Shimada, C. Ra, Most highly cytokinergic IgEs have polyreactivity to autoantigens, Allergy Asthma Immunol Res, Vol. 4, 2012, 332-340 7 T.W. Chang, C. Chen, C.J. Lin, M. Metz, M.K. Church, M. Maurer, The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria, J Allergy Clin Immunol, Vol. 135, 2015, 337-342 8 A.P. Kaplan, A.M. Gimenez-Arnau, S.S. 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Drug dosages
Drug therapy
Immunoglobulin E
Immunotherapy
Monoclonal antibodies
Urticaria
title Omalizumab for severe chronic spontaneous urticaria: Real-life experiences of 280 patients
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