Choosing the Active X: The Human Version of X Inactivation

Humans and rodents differ in how they carry out X inactivation (XI), the mammalian method to compensate for the different number of X chromosomes in males and females. Evolutionary changes in staging embryogenesis and in mutations within the XI center alter the process among mammals. The mouse model...

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Veröffentlicht in:	Trends in genetics 2017-12, Vol.33 (12), p.899-909
1. Verfasser:	Migeon, Barbara R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autosomal repressor of XIST Biological Evolution Dosage Compensation, Genetic - genetics Female Gene Silencing - physiology Humans Male Mammals - physiology Mice RNA, Untranslated - genetics single active X species differences in X inactivation X Chromosome - genetics X Chromosome Inactivation - genetics X dosage compensation X inactivation
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