Synaptic Activity Protects Neurons Against Calcium-Mediated Oxidation and Contraction of Mitochondria During Excitotoxicity

Excitotoxicity triggered by extrasynaptic N-methyl-d-aspartate-type glutamate receptors has been implicated in many neurodegenerative conditions, including Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and stroke. Mitochondrial calcium overload leading to mitoch...

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Veröffentlicht in:	Antioxidants & redox signaling 2018-10, Vol.29 (12), p.1109-1124
Hauptverfasser:	Depp, Constanze, Bas-Orth, Carlos, Schroeder, Lisa, Hellwig, Andrea, Bading, Hilmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyotrophic lateral sclerosis Calcium Calcium (mitochondrial) Contraction Excitotoxicity Fluorescence Gene silencing Glutamic acid receptors Glutaredoxin Glutathione Green fluorescent protein Hippocampus Huntington's disease Innovations Mitochondria Neurodegenerative diseases Neurological diseases Neurons Neuroprotection Oxidation Oxidative stress Proteins Reactive oxygen species Receptors Redox potential Rodents Stroke Therapeutic targets
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