Taurine alleviates malathion induced lipid peroxidation, oxidative stress, and proinflammatory cytokine gene expressions in rats
[Display omitted] The present study was considered to evaluate the protective effect of taurine on malathion-induced toxicity in rats. Totally, 48 male rats were divided into 6 equal groups: 0.5ml physiological salt solution was given orally to control rats. 0.5ml corn oil was given orally to rats i...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2017-12, Vol.96, p.263-268 |
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| creator | Ince, Sinan Arslan-Acaroz, Damla Demirel, Hasan Huseyin Varol, Nuray Ozyurek, Hatice Arzu Zemheri, Fahriye Kucukkurt, Ismail |
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The present study was considered to evaluate the protective effect of taurine on malathion-induced toxicity in rats. Totally, 48 male rats were divided into 6 equal groups: 0.5ml physiological salt solution was given orally to control rats. 0.5ml corn oil was given orally to rats in corn oil group. Malathion at dose of 27mg/kg (1/50 of LD50) was dissolved in 0.5ml corn oil and given to orally rats in malathion group. The other groups; malathion (27mg/kg) and taurine (dissolved in 0.5ml physiological salt solution) at dose of 50, 100, and 200mg/kg were given orally to rats for 30days, respectively. Malathion treatment decreased acetylcholinesterase levels in serum (30%) and liver (25%) compared to the control group. Malathion resulted in a significant increase in malondialdehyde levels whereas decreased glutathione levels, superoxide dismutase, and catalase activities in rats. Also, IF-γ, IL1-β, TNF-α, and NFĸB mRNA expression levels were found to be increased 5, 1.7, 2.3, and 2.5 fold in malathion treated rats compared to control, respectively. However, treatment of taurine, in a dose-dependent manner, resulted in a reversal of malathion-induced lipid peroxidation, antioxidant enzyme activities, and mRNA expression levels of proinflammatory cytokines. Moreover, taurine demonstrated preventive action against malathion-induced histopathological changes in rat tissues. In conclusion, taurine exhibited a protective effect in rats against malathion-induced lipid peroxidation, besides it ameliorated antioxidant status, decreased mRNA expression levels of proinflammatory cytokine and repaired rat tissues. |
| doi_str_mv | 10.1016/j.biopha.2017.09.141 |
| format | Article |
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The present study was considered to evaluate the protective effect of taurine on malathion-induced toxicity in rats. Totally, 48 male rats were divided into 6 equal groups: 0.5ml physiological salt solution was given orally to control rats. 0.5ml corn oil was given orally to rats in corn oil group. Malathion at dose of 27mg/kg (1/50 of LD50) was dissolved in 0.5ml corn oil and given to orally rats in malathion group. The other groups; malathion (27mg/kg) and taurine (dissolved in 0.5ml physiological salt solution) at dose of 50, 100, and 200mg/kg were given orally to rats for 30days, respectively. Malathion treatment decreased acetylcholinesterase levels in serum (30%) and liver (25%) compared to the control group. Malathion resulted in a significant increase in malondialdehyde levels whereas decreased glutathione levels, superoxide dismutase, and catalase activities in rats. Also, IF-γ, IL1-β, TNF-α, and NFĸB mRNA expression levels were found to be increased 5, 1.7, 2.3, and 2.5 fold in malathion treated rats compared to control, respectively. However, treatment of taurine, in a dose-dependent manner, resulted in a reversal of malathion-induced lipid peroxidation, antioxidant enzyme activities, and mRNA expression levels of proinflammatory cytokines. Moreover, taurine demonstrated preventive action against malathion-induced histopathological changes in rat tissues. In conclusion, taurine exhibited a protective effect in rats against malathion-induced lipid peroxidation, besides it ameliorated antioxidant status, decreased mRNA expression levels of proinflammatory cytokine and repaired rat tissues.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2017.09.141</identifier><identifier>PMID: 28987951</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Histopathology ; Lipid peroxidation ; Malathion ; Proinflammatory cytokines ; Rat ; Taurine</subject><ispartof>Biomedicine & pharmacotherapy, 2017-12, Vol.96, p.263-268</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier Masson SAS.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-5ccf4fd4d8c9d22327f49dad7ccc81a7e8c51fa463858162bd55cd8470afb5a03</citedby><cites>FETCH-LOGICAL-c362t-5ccf4fd4d8c9d22327f49dad7ccc81a7e8c51fa463858162bd55cd8470afb5a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2017.09.141$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28987951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ince, Sinan</creatorcontrib><creatorcontrib>Arslan-Acaroz, Damla</creatorcontrib><creatorcontrib>Demirel, Hasan Huseyin</creatorcontrib><creatorcontrib>Varol, Nuray</creatorcontrib><creatorcontrib>Ozyurek, Hatice Arzu</creatorcontrib><creatorcontrib>Zemheri, Fahriye</creatorcontrib><creatorcontrib>Kucukkurt, Ismail</creatorcontrib><title>Taurine alleviates malathion induced lipid peroxidation, oxidative stress, and proinflammatory cytokine gene expressions in rats</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>[Display omitted]
The present study was considered to evaluate the protective effect of taurine on malathion-induced toxicity in rats. Totally, 48 male rats were divided into 6 equal groups: 0.5ml physiological salt solution was given orally to control rats. 0.5ml corn oil was given orally to rats in corn oil group. Malathion at dose of 27mg/kg (1/50 of LD50) was dissolved in 0.5ml corn oil and given to orally rats in malathion group. The other groups; malathion (27mg/kg) and taurine (dissolved in 0.5ml physiological salt solution) at dose of 50, 100, and 200mg/kg were given orally to rats for 30days, respectively. Malathion treatment decreased acetylcholinesterase levels in serum (30%) and liver (25%) compared to the control group. Malathion resulted in a significant increase in malondialdehyde levels whereas decreased glutathione levels, superoxide dismutase, and catalase activities in rats. Also, IF-γ, IL1-β, TNF-α, and NFĸB mRNA expression levels were found to be increased 5, 1.7, 2.3, and 2.5 fold in malathion treated rats compared to control, respectively. However, treatment of taurine, in a dose-dependent manner, resulted in a reversal of malathion-induced lipid peroxidation, antioxidant enzyme activities, and mRNA expression levels of proinflammatory cytokines. Moreover, taurine demonstrated preventive action against malathion-induced histopathological changes in rat tissues. In conclusion, taurine exhibited a protective effect in rats against malathion-induced lipid peroxidation, besides it ameliorated antioxidant status, decreased mRNA expression levels of proinflammatory cytokine and repaired rat tissues.</description><subject>Histopathology</subject><subject>Lipid peroxidation</subject><subject>Malathion</subject><subject>Proinflammatory cytokines</subject><subject>Rat</subject><subject>Taurine</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kM1u1DAURi0EokPLGyDkJYsm2E6c2BskVNGCVIlNWVt37BvqIYmD7Yw6Ox69Hs3Ako1tyee7P4eQd5zVnPHu467e-rA8Qi0Y72uma97yF2TDtWRVx1j_kmxYL5uqaYS4IG9S2jHGZNeo1-RCKK16LfmG_HmANfoZKYwj7j1kTHSCEfKjDzP1s1stOjr6xTu6YAxP3kEuX9f0_NwjTTliStcU5sLE4OdhhGmCHOKB2kMOv471f2I58Gk5oiWfSm0aIacr8mqAMeHb831Jftx-ebj5Wt1_v_t28_m-sk0nciWtHdrBtU5Z7YRoRD-02oHrrbWKQ4_KSj5AW_aTindi66S0TrU9g2ErgTWX5MOpbpnw94opm8kni-MIM4Y1Ga5bzVTX9Lqg7Qm1MaQUcTBL9BPEg-HMHN2bnTm5N0f3hmlT3JfY-3OHdTuh-xf6K7sAn04Alj33HqNJ1uNcBPuINhsX_P87PAN2PZt9</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Ince, Sinan</creator><creator>Arslan-Acaroz, Damla</creator><creator>Demirel, Hasan Huseyin</creator><creator>Varol, Nuray</creator><creator>Ozyurek, Hatice Arzu</creator><creator>Zemheri, Fahriye</creator><creator>Kucukkurt, Ismail</creator><general>Elsevier Masson SAS</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201712</creationdate><title>Taurine alleviates malathion induced lipid peroxidation, oxidative stress, and proinflammatory cytokine gene expressions in rats</title><author>Ince, Sinan ; Arslan-Acaroz, Damla ; Demirel, Hasan Huseyin ; Varol, Nuray ; Ozyurek, Hatice Arzu ; Zemheri, Fahriye ; Kucukkurt, Ismail</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-5ccf4fd4d8c9d22327f49dad7ccc81a7e8c51fa463858162bd55cd8470afb5a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Histopathology</topic><topic>Lipid peroxidation</topic><topic>Malathion</topic><topic>Proinflammatory cytokines</topic><topic>Rat</topic><topic>Taurine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ince, Sinan</creatorcontrib><creatorcontrib>Arslan-Acaroz, Damla</creatorcontrib><creatorcontrib>Demirel, Hasan Huseyin</creatorcontrib><creatorcontrib>Varol, Nuray</creatorcontrib><creatorcontrib>Ozyurek, Hatice Arzu</creatorcontrib><creatorcontrib>Zemheri, Fahriye</creatorcontrib><creatorcontrib>Kucukkurt, Ismail</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ince, Sinan</au><au>Arslan-Acaroz, Damla</au><au>Demirel, Hasan Huseyin</au><au>Varol, Nuray</au><au>Ozyurek, Hatice Arzu</au><au>Zemheri, Fahriye</au><au>Kucukkurt, Ismail</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Taurine alleviates malathion induced lipid peroxidation, oxidative stress, and proinflammatory cytokine gene expressions in rats</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2017-12</date><risdate>2017</risdate><volume>96</volume><spage>263</spage><epage>268</epage><pages>263-268</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>[Display omitted]
The present study was considered to evaluate the protective effect of taurine on malathion-induced toxicity in rats. Totally, 48 male rats were divided into 6 equal groups: 0.5ml physiological salt solution was given orally to control rats. 0.5ml corn oil was given orally to rats in corn oil group. Malathion at dose of 27mg/kg (1/50 of LD50) was dissolved in 0.5ml corn oil and given to orally rats in malathion group. The other groups; malathion (27mg/kg) and taurine (dissolved in 0.5ml physiological salt solution) at dose of 50, 100, and 200mg/kg were given orally to rats for 30days, respectively. Malathion treatment decreased acetylcholinesterase levels in serum (30%) and liver (25%) compared to the control group. Malathion resulted in a significant increase in malondialdehyde levels whereas decreased glutathione levels, superoxide dismutase, and catalase activities in rats. Also, IF-γ, IL1-β, TNF-α, and NFĸB mRNA expression levels were found to be increased 5, 1.7, 2.3, and 2.5 fold in malathion treated rats compared to control, respectively. However, treatment of taurine, in a dose-dependent manner, resulted in a reversal of malathion-induced lipid peroxidation, antioxidant enzyme activities, and mRNA expression levels of proinflammatory cytokines. Moreover, taurine demonstrated preventive action against malathion-induced histopathological changes in rat tissues. In conclusion, taurine exhibited a protective effect in rats against malathion-induced lipid peroxidation, besides it ameliorated antioxidant status, decreased mRNA expression levels of proinflammatory cytokine and repaired rat tissues.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>28987951</pmid><doi>10.1016/j.biopha.2017.09.141</doi><tpages>6</tpages></addata></record> |
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| subjects | Histopathology Lipid peroxidation Malathion Proinflammatory cytokines Rat Taurine |
| title | Taurine alleviates malathion induced lipid peroxidation, oxidative stress, and proinflammatory cytokine gene expressions in rats |
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