Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma
A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents...
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| Veröffentlicht in: | Trends in cell biology 2017-11, Vol.27 (11), p.785-786 |
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| creator | Tsegaye, Matyas Abel Schafer, Zachary T. |
| description | A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated protein kinase (AMPK)-mediated anoikis, and consequently promotes PDAC development and metastasis. |
| doi_str_mv | 10.1016/j.tcb.2017.09.003 |
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| fulltext | fulltext |
| identifier | ISSN: 0962-8924 |
| ispartof | Trends in cell biology, 2017-11, Vol.27 (11), p.785-786 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adenocarcinoma AMP AMP-activated protein kinase AMP-Activated Protein Kinases Anoikis Carcinoma, Pancreatic Ductal Fluorescence Glucose glucose metabolism Glucose transporter Glucose transporter 1 Humans Kinases Metastases Metastasis Pancreas Pancreatic cancer pancreatic ductal adenocarcinoma Paraoxonase Tumors |
| title | Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma |
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