Identification and characterization of an angiotensin-converting enzyme inhibitory peptide derived from bovine casein

•A casein-derived angiotensin I-converting enzyme inhibitory peptide, YQKFPQYLQY (YQK) was purified and identified, with its IC50 value of 11.068 μM.•The inhibitory mode of YQK was competitive.•YQK was stable against heat, pH and the gastrointestinal enzymes pepsin and trypsin.•Significant decreases...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2018-01, Vol.99, p.161-168
Hauptverfasser:	Xue, Lu, Wang, Xiaodan, Hu, Zhihe, Wu, Zijian, Wang, Lijuan, Wang, Hui, Yang, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitory pattern ACE inhibitory peptide Angiotensin-Converting Enzyme Inhibitors - chemistry Angiotensin-Converting Enzyme Inhibitors - isolation & purification Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive Agents - chemistry Antihypertensive Agents - isolation & purification Antihypertensive Agents - pharmacology Antihypertensive effect Casein Caseins - chemistry Cattle Hypertension - drug therapy Hypertension - metabolism Hypertension - pathology Male Oligopeptides - chemistry Oligopeptides - isolation & purification Oligopeptides - pharmacology Rats Rats, Inbred SHR Rats, Wistar Stability against digestive enzymes
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