MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes

The members of the miR-17-92 cluster are upregulated in various cancers and function as a cluster of oncogenic miRNA. Our study characterized a new function of miR-17-5p, a member of the miR-17-92 cluster, in regulating cell proliferation in pancreatic cancer. Our results indicate that miR-17-5p was...

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Veröffentlicht in:	Cancer letters 2018-01, Vol.412, p.59-68
Hauptverfasser:	Zhu, Youwei, Gu, Jiangning, Li, Ying, Peng, Chenghong, Shi, Minmin, Wang, Xuelong, Wei, Gang, Ge, Ouyang, Wang, Di, Zhang, Bosen, Wu, Jian, Zhong, Yiming, Shen, Baiyong, Chen, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - pathology Carcinoma, Pancreatic Ductal - pathology Cell adhesion & migration Cell Cycle Cell Line, Tumor Cell Proliferation Cloning Deoxyribonucleic acid DNA E2F protein E2F4 E2F4 Transcription Factor - genetics E2F4 Transcription Factor - physiology Gene expression Genomes Humans Medical prognosis MicroRNAs - physiology miR-17-5p miRNA Pancreatic cancer Pancreatic Neoplasms - pathology Plasmids Proteins RBL2 Retina Retinoblastoma Retinoblastoma-Like Protein p130 - genetics Retinoblastoma-Like Protein p130 - physiology Transcription factors Tumor suppressor genes Tumors
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