Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study
Aim To evaluate the association between periodontal disease and pneumonia mortality in haemodialysis patients. Materials and Methods This prospective cohort study included 211 patients (mean age, 64.4 years) undergoing haemodialysis at a single medical centre. The patients underwent a baseline clini...
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| Veröffentlicht in: | Journal of clinical periodontology 2018-01, Vol.45 (1), p.38-45 |
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| creator | Iwasaki, Masanori Taylor, George W. Awano, Shuji Yoshida, Akihiro Kataoka, Shota Ansai, Toshihiro Nakamura, Hidetoshi |
| description | Aim
To evaluate the association between periodontal disease and pneumonia mortality in haemodialysis patients.
Materials and Methods
This prospective cohort study included 211 patients (mean age, 64.4 years) undergoing haemodialysis at a single medical centre. The patients underwent a baseline clinical dental examination in 2008 and were then followed up until July 2015. Periodontal disease was defined as the presence of clinical attachment loss of ≥4 mm in ≥30% of the probed sites. The primary endpoint, that is death from pneumonia, was determined by reviewing death certificates and was analysed using the competing‐risks regression model.
Results
At baseline, 92 patients (43.6%) had periodontal disease. The median follow‐up period was 84 months (interquartile range, 36–86 months). Of the 68 deaths that occurred, 21 were from pneumonia. The multivariable competing‐risks regression model showed that periodontal disease was significantly associated with death from pneumonia (adjusted subhazard ratio, 3.49; 95% confidence interval, 1.14–10.64), after adjusting for other baseline health characteristics.
Conclusions
The results of this study suggest that periodontal disease is independently associated with pneumonia mortality in haemodialysis patients. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on pneumonia in haemodialysis patients would be of great interest. |
| doi_str_mv | 10.1111/jcpe.12828 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1948759868</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1948759868</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4238-e9c75346284eb78cd55d8486acc7c9decd456571d0630a9785b17a220eebafaa3</originalsourceid><addsrcrecordid>eNp9kMFu1DAQQC1URLeFCx9QWeoFVUqxYzt2elut2gKqRA8gcSKatWdVr5I4tRNVufEJfCNfgpddOPSAL3Pwm6fRI-QtZ5c8v_dbO-AlL01pXpAFrxgrmOLfjsiCCSaKqtb1MTlJacsY10KIV-S4NLVRUpYL8v0eow8u9CO01PmEkJBC7-jQ49SF3gPtQsyffpyp7-kDYBech3ZOPtEBRo_9mK7okupfP37OCJHa8JA3aBonN78mLzfQJnxzmKfk6831l9WH4u7z7cfV8q6wshSmwNpqJWRVGolrbaxTyhlpKrBW29qhdVJVSnPHKsGg1katuYayZIhr2ACIU_Ju7x1ieJwwjU3nk8W2hR7DlBpeS6NVbSqT0fNn6DZMsc_XZUprLmVumqmLPWVjSCniphmi7yDODWfNrnqzq978qZ7hs4NyWnfo_qF_M2eA74En3-L8H1XzaXV_vZf-Bigzji4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1977144111</pqid></control><display><type>article</type><title>Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study</title><source>Wiley Online Library - AutoHoldings Journals</source><creator>Iwasaki, Masanori ; Taylor, George W. ; Awano, Shuji ; Yoshida, Akihiro ; Kataoka, Shota ; Ansai, Toshihiro ; Nakamura, Hidetoshi</creator><creatorcontrib>Iwasaki, Masanori ; Taylor, George W. ; Awano, Shuji ; Yoshida, Akihiro ; Kataoka, Shota ; Ansai, Toshihiro ; Nakamura, Hidetoshi</creatorcontrib><description>Aim
To evaluate the association between periodontal disease and pneumonia mortality in haemodialysis patients.
Materials and Methods
This prospective cohort study included 211 patients (mean age, 64.4 years) undergoing haemodialysis at a single medical centre. The patients underwent a baseline clinical dental examination in 2008 and were then followed up until July 2015. Periodontal disease was defined as the presence of clinical attachment loss of ≥4 mm in ≥30% of the probed sites. The primary endpoint, that is death from pneumonia, was determined by reviewing death certificates and was analysed using the competing‐risks regression model.
Results
At baseline, 92 patients (43.6%) had periodontal disease. The median follow‐up period was 84 months (interquartile range, 36–86 months). Of the 68 deaths that occurred, 21 were from pneumonia. The multivariable competing‐risks regression model showed that periodontal disease was significantly associated with death from pneumonia (adjusted subhazard ratio, 3.49; 95% confidence interval, 1.14–10.64), after adjusting for other baseline health characteristics.
Conclusions
The results of this study suggest that periodontal disease is independently associated with pneumonia mortality in haemodialysis patients. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on pneumonia in haemodialysis patients would be of great interest.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.12828</identifier><identifier>PMID: 28985442</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Cohort analysis ; cohort studies ; Death ; Dentistry ; epidemiology ; Gum disease ; Hemodialysis ; kidney diseases ; Mortality ; oral health ; Periodontics ; periodontitis ; Pneumonia ; renal dialysis</subject><ispartof>Journal of clinical periodontology, 2018-01, Vol.45 (1), p.38-45</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4238-e9c75346284eb78cd55d8486acc7c9decd456571d0630a9785b17a220eebafaa3</citedby><cites>FETCH-LOGICAL-c4238-e9c75346284eb78cd55d8486acc7c9decd456571d0630a9785b17a220eebafaa3</cites><orcidid>0000-0002-5739-2936</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.12828$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.12828$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28985442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwasaki, Masanori</creatorcontrib><creatorcontrib>Taylor, George W.</creatorcontrib><creatorcontrib>Awano, Shuji</creatorcontrib><creatorcontrib>Yoshida, Akihiro</creatorcontrib><creatorcontrib>Kataoka, Shota</creatorcontrib><creatorcontrib>Ansai, Toshihiro</creatorcontrib><creatorcontrib>Nakamura, Hidetoshi</creatorcontrib><title>Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
To evaluate the association between periodontal disease and pneumonia mortality in haemodialysis patients.
Materials and Methods
This prospective cohort study included 211 patients (mean age, 64.4 years) undergoing haemodialysis at a single medical centre. The patients underwent a baseline clinical dental examination in 2008 and were then followed up until July 2015. Periodontal disease was defined as the presence of clinical attachment loss of ≥4 mm in ≥30% of the probed sites. The primary endpoint, that is death from pneumonia, was determined by reviewing death certificates and was analysed using the competing‐risks regression model.
Results
At baseline, 92 patients (43.6%) had periodontal disease. The median follow‐up period was 84 months (interquartile range, 36–86 months). Of the 68 deaths that occurred, 21 were from pneumonia. The multivariable competing‐risks regression model showed that periodontal disease was significantly associated with death from pneumonia (adjusted subhazard ratio, 3.49; 95% confidence interval, 1.14–10.64), after adjusting for other baseline health characteristics.
Conclusions
The results of this study suggest that periodontal disease is independently associated with pneumonia mortality in haemodialysis patients. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on pneumonia in haemodialysis patients would be of great interest.</description><subject>Cohort analysis</subject><subject>cohort studies</subject><subject>Death</subject><subject>Dentistry</subject><subject>epidemiology</subject><subject>Gum disease</subject><subject>Hemodialysis</subject><subject>kidney diseases</subject><subject>Mortality</subject><subject>oral health</subject><subject>Periodontics</subject><subject>periodontitis</subject><subject>Pneumonia</subject><subject>renal dialysis</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMFu1DAQQC1URLeFCx9QWeoFVUqxYzt2elut2gKqRA8gcSKatWdVr5I4tRNVufEJfCNfgpddOPSAL3Pwm6fRI-QtZ5c8v_dbO-AlL01pXpAFrxgrmOLfjsiCCSaKqtb1MTlJacsY10KIV-S4NLVRUpYL8v0eow8u9CO01PmEkJBC7-jQ49SF3gPtQsyffpyp7-kDYBech3ZOPtEBRo_9mK7okupfP37OCJHa8JA3aBonN78mLzfQJnxzmKfk6831l9WH4u7z7cfV8q6wshSmwNpqJWRVGolrbaxTyhlpKrBW29qhdVJVSnPHKsGg1katuYayZIhr2ACIU_Ju7x1ieJwwjU3nk8W2hR7DlBpeS6NVbSqT0fNn6DZMsc_XZUprLmVumqmLPWVjSCniphmi7yDODWfNrnqzq978qZ7hs4NyWnfo_qF_M2eA74En3-L8H1XzaXV_vZf-Bigzji4</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Iwasaki, Masanori</creator><creator>Taylor, George W.</creator><creator>Awano, Shuji</creator><creator>Yoshida, Akihiro</creator><creator>Kataoka, Shota</creator><creator>Ansai, Toshihiro</creator><creator>Nakamura, Hidetoshi</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5739-2936</orcidid></search><sort><creationdate>201801</creationdate><title>Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study</title><author>Iwasaki, Masanori ; Taylor, George W. ; Awano, Shuji ; Yoshida, Akihiro ; Kataoka, Shota ; Ansai, Toshihiro ; Nakamura, Hidetoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4238-e9c75346284eb78cd55d8486acc7c9decd456571d0630a9785b17a220eebafaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cohort analysis</topic><topic>cohort studies</topic><topic>Death</topic><topic>Dentistry</topic><topic>epidemiology</topic><topic>Gum disease</topic><topic>Hemodialysis</topic><topic>kidney diseases</topic><topic>Mortality</topic><topic>oral health</topic><topic>Periodontics</topic><topic>periodontitis</topic><topic>Pneumonia</topic><topic>renal dialysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwasaki, Masanori</creatorcontrib><creatorcontrib>Taylor, George W.</creatorcontrib><creatorcontrib>Awano, Shuji</creatorcontrib><creatorcontrib>Yoshida, Akihiro</creatorcontrib><creatorcontrib>Kataoka, Shota</creatorcontrib><creatorcontrib>Ansai, Toshihiro</creatorcontrib><creatorcontrib>Nakamura, Hidetoshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwasaki, Masanori</au><au>Taylor, George W.</au><au>Awano, Shuji</au><au>Yoshida, Akihiro</au><au>Kataoka, Shota</au><au>Ansai, Toshihiro</au><au>Nakamura, Hidetoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2018-01</date><risdate>2018</risdate><volume>45</volume><issue>1</issue><spage>38</spage><epage>45</epage><pages>38-45</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
To evaluate the association between periodontal disease and pneumonia mortality in haemodialysis patients.
Materials and Methods
This prospective cohort study included 211 patients (mean age, 64.4 years) undergoing haemodialysis at a single medical centre. The patients underwent a baseline clinical dental examination in 2008 and were then followed up until July 2015. Periodontal disease was defined as the presence of clinical attachment loss of ≥4 mm in ≥30% of the probed sites. The primary endpoint, that is death from pneumonia, was determined by reviewing death certificates and was analysed using the competing‐risks regression model.
Results
At baseline, 92 patients (43.6%) had periodontal disease. The median follow‐up period was 84 months (interquartile range, 36–86 months). Of the 68 deaths that occurred, 21 were from pneumonia. The multivariable competing‐risks regression model showed that periodontal disease was significantly associated with death from pneumonia (adjusted subhazard ratio, 3.49; 95% confidence interval, 1.14–10.64), after adjusting for other baseline health characteristics.
Conclusions
The results of this study suggest that periodontal disease is independently associated with pneumonia mortality in haemodialysis patients. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on pneumonia in haemodialysis patients would be of great interest.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>28985442</pmid><doi>10.1111/jcpe.12828</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5739-2936</orcidid></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | Cohort analysis cohort studies Death Dentistry epidemiology Gum disease Hemodialysis kidney diseases Mortality oral health Periodontics periodontitis Pneumonia renal dialysis |
| title | Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study |
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