Modulation of mitochondrial dynamics by treadmill training to improve gait and mitochondrial deficiency in a rat model of Parkinson's disease

Parkinson's disease (PD) is a progressive degenerative central nervous system disorder that particularly impairs motor function. As PD advances, gait disorders become more pronounced and are often difficult to treat with current pharmacological therapies. Physical activity improves both mobilit...

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Veröffentlicht in:	Life sciences (1973) 2017-12, Vol.191, p.236-244
Hauptverfasser:	Chuang, Chieh-Sen, Chang, Jui-Chih, Cheng, Fu-Chou, Liu, Ko-Hung, Su, Hong-Lin, Liu, Chin-San
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Animal behavior Animals Balance Central nervous system Corpus Striatum - metabolism Corpus Striatum - physiopathology Degeneration Disease Models, Animal Dopamine receptors Exercise Therapy Female Fission Fitness equipment Gait Methamphetamine Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondrial Dynamics Motor Activity Movement disorders Neostriatum Neurodegeneration Neurodegenerative diseases Oxidative Stress Parkinson Disease - metabolism Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's disease Pharmacology Physical activity Physical Conditioning, Animal Physical training Proteins Rats Rats, Sprague-Dawley Rodents Studies Substantia nigra Substantia Nigra - metabolism Substantia Nigra - physiopathology Test procedures Training Treadmill Treadmills Viability
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