Synaptopathology in autism spectrum disorders: Complex effects of synaptic genes on neural circuits

•Summary of connectivity alterations in human ASD brains•Outline of neural circuits for main behavioral features of ASDs•Review of alteration of GABAergic and Glutamatergic synaptic transmission system in ASDs•Review of alteration of structural and functional plasticity in ASDs

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Bibliographische Detailangaben
Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2018-06, Vol.84 (Pt B), p.398-415
Hauptverfasser:	Wang, Xinxing, Kery, Rachel, Xiong, Qiaojie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism Spectrum Disorder - genetics Autism Spectrum Disorder - pathology Brain - metabolism Brain - pathology gamma-Aminobutyric Acid - genetics gamma-Aminobutyric Acid - metabolism Glutamic Acid - genetics Glutamic Acid - metabolism Humans Synapses - genetics Synapses - pathology Synaptic Transmission - physiology
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Beschreibung
Zusammenfassung:	•Summary of connectivity alterations in human ASD brains•Outline of neural circuits for main behavioral features of ASDs•Review of alteration of GABAergic and Glutamatergic synaptic transmission system in ASDs•Review of alteration of structural and functional plasticity in ASDs
ISSN:	0278-5846 1878-4216
DOI:	10.1016/j.pnpbp.2017.09.026