High-mobility group box 1 protein is involved in the protective effect of Saquinavir on ventilation-induced lung injury in mice

Saquinavir （SQV） is the first FDA approved HIV protease inhibitor. Previous studies showed that SQV can limit Toll-like receptor-4 （TLR4）-mediated inflammatory pathway and nuclear factor-κB （NF-κB） activation, thereby playing a protective role in many kinds of diseases. High-mobility group box 1 （HM...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2017-10, Vol.49 (10), p.907-915
Hauptverfasser:	Wang, Xin, Zhang, Renlingzi, Tong, Yao, Ding, Xibing, Jin, Shuqing, Zhao, Xiang, Zong, Jiaying, Chen, Zhixia, Billiar, Timothy R, Li, Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchoalveolar Lavage Fluid - chemistry HIV Protease Inhibitors - pharmacology HMGB1 Protein - genetics HMGB1 Protein - metabolism Interleukin-6 - blood Interleukin-6 - metabolism Lung - metabolism Lung - pathology Lung - physiopathology Mice, Inbred C57BL NF-kappa B - metabolism Protective Agents - pharmacology Random Allocation Saquinavir - pharmacology Tidal Volume Toll样受体4 Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - metabolism Ventilator-Induced Lung Injury - metabolism Ventilator-Induced Lung Injury - physiopathology Ventilator-Induced Lung Injury - prevention & control 保护作用呼吸机小鼠支气管肺泡灌洗液肺损伤蛋白酶抑制剂迁移率
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