Palladium-Catalyzed Imidoylative Cyclization of Tryptophan-Derived Isocyanides: Access to β‑Carbolines

A palladium-catalyzed imidoylative cyclization of ethyl-3-(1H-indol-3-yl)-2-isocyanopropanoates, derived from readily available tryptophan, to afford β-carboline derivatives has been developed. The reaction proceeds smoothly under mild conditions through sequential isocyanide insertion, intramolecul...

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Veröffentlicht in:	Organic letters 2017-10, Vol.19 (20), p.5577-5580
Hauptverfasser:	Tang, Shi, Wang, Jian, Xiong, Zhuang, Xie, Zeqiang, Li, Dengke, Huang, Jinbo, Zhu, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbolines Catalysis Cyanides Cyclization Molecular Structure Palladium Tryptophan - chemistry
Online-Zugang:	Volltext
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