Continuous versus pulsatile administration of rotigotine in 6-OHDA-lesioned rats: contralateral rotations and abnormal involuntary movements

Sustained drug delivery providing continuous dopaminergic stimulation is thought to prevent or delay the induction of motor complications (dyskinesia) in Parkinson’s disease, whereas pulsatile administration is supposed to promote them. This study investigated the inducibility of sensitization and a...

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Veröffentlicht in:	Journal of Neural Transmission 2008-10, Vol.115 (10), p.1385-1392
Hauptverfasser:	Schmidt, Werner J., Lebsanft, Heike, Heindl, Manfred, Gerlach, Manfred, Gruenblatt, Edna, Riederer, Peter, Mayerhofer, Andreas, Scheller, Dieter K. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Agents - toxicity Animals Basic Neurosciences Dopamine Agonists - administration & dosage Dyskinesia, Drug-Induced Dyskinesias - drug therapy Genetics and Immunology - Original Article Male Medicine Medicine & Public Health Neurology Neurosciences Oxidopamine - toxicity Parkinsonian Disorders - complications Parkinsonian Disorders - drug therapy Psychiatry Rats Rats, Sprague-Dawley Rotation Tetrahydronaphthalenes - administration & dosage Thiophenes - administration & dosage
Online-Zugang:	Volltext
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