Altered vesicular dopamine storage in Parkinson's disease: a premature demise

Dopamine is a potentially toxic neurotransmitter that has long been speculated to contribute to the pathogenesis of Parkinson's disease (PD). Recent work has demonstrated the importance of proper storage of dopamine in vesicles to maintain dopamine homeostasis, thus protecting neurons from the...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2008-06, Vol.31 (6), p.303-308
Hauptverfasser:	Caudle, W. Michael, Colebrooke, Rebecca E, Emson, Piers C, Miller, Gary W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Fundamental and applied biological sciences. Psychology Genetics Humans Medical sciences Neurology Neurons Neurons - metabolism Neurosciences Neurotransmitters Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Studies Synucleins - metabolism Vertebrates: nervous system and sense organs Vesicular Monoamine Transport Proteins - genetics
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