Altered vesicular dopamine storage in Parkinson's disease: a premature demise
Dopamine is a potentially toxic neurotransmitter that has long been speculated to contribute to the pathogenesis of Parkinson's disease (PD). Recent work has demonstrated the importance of proper storage of dopamine in vesicles to maintain dopamine homeostasis, thus protecting neurons from the...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2008-06, Vol.31 (6), p.303-308 |
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| container_title | Trends in neurosciences (Regular ed.) |
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| creator | Caudle, W. Michael Colebrooke, Rebecca E Emson, Piers C Miller, Gary W |
| description | Dopamine is a potentially toxic neurotransmitter that has long been speculated to contribute to the pathogenesis of Parkinson's disease (PD). Recent work has demonstrated the importance of proper storage of dopamine in vesicles to maintain dopamine homeostasis, thus protecting neurons from the detrimental effects of dopamine accumulation and breakdown in the cytosol. These studies suggest that factors which affect dopamine storage might increase the susceptibility of dopamine neurons to further environmental or genetic insults, exacerbating the neuronal degeneration that characterizes PD. This review seeks to revisit the pathogenicity of cytosolic dopamine and further address the critical role of neurotransmitter storage in dopamine-mediated neurotoxicity. |
| doi_str_mv | 10.1016/j.tins.2008.02.010 |
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This review seeks to revisit the pathogenicity of cytosolic dopamine and further address the critical role of neurotransmitter storage in dopamine-mediated neurotoxicity.</description><identifier>ISSN: 0166-2236</identifier><identifier>EISSN: 1878-108X</identifier><identifier>DOI: 10.1016/j.tins.2008.02.010</identifier><identifier>PMID: 18471904</identifier><identifier>CODEN: TNSCDR</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dopamine - metabolism ; Fundamental and applied biological sciences. 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Michael</creatorcontrib><creatorcontrib>Colebrooke, Rebecca E</creatorcontrib><creatorcontrib>Emson, Piers C</creatorcontrib><creatorcontrib>Miller, Gary W</creatorcontrib><title>Altered vesicular dopamine storage in Parkinson's disease: a premature demise</title><title>Trends in neurosciences (Regular ed.)</title><addtitle>Trends Neurosci</addtitle><description>Dopamine is a potentially toxic neurotransmitter that has long been speculated to contribute to the pathogenesis of Parkinson's disease (PD). Recent work has demonstrated the importance of proper storage of dopamine in vesicles to maintain dopamine homeostasis, thus protecting neurons from the detrimental effects of dopamine accumulation and breakdown in the cytosol. These studies suggest that factors which affect dopamine storage might increase the susceptibility of dopamine neurons to further environmental or genetic insults, exacerbating the neuronal degeneration that characterizes PD. 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| ispartof | Trends in neurosciences (Regular ed.), 2008-06, Vol.31 (6), p.303-308 |
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| subjects | Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Fundamental and applied biological sciences. Psychology Genetics Humans Medical sciences Neurology Neurons Neurons - metabolism Neurosciences Neurotransmitters Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Studies Synucleins - metabolism Vertebrates: nervous system and sense organs Vesicular Monoamine Transport Proteins - genetics |
| title | Altered vesicular dopamine storage in Parkinson's disease: a premature demise |
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