Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

Gemcitabine triphosphate (dFdCTP) is a highly active metabolite of gemcitabine. It is formed intra‐cellularly via the phosphorylation of gemcitabine by deoxycytidine kinase. The monitoring of dFdCTP in human peripheral blood mononuclear cells (PBMCs), in addition to plasma concentrations of gemcitab...

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Veröffentlicht in:	Journal of mass spectrometry. 2006-12, Vol.41 (12), p.1633-1642
Hauptverfasser:	Veltkamp, S. A., Hillebrand, M. J. X., Rosing, H., Jansen, R. S., Wickremsinhe, E. R., Perkins, E. J., Schellens, J. H. M., Beijnen, J. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anions Antimetabolites, Antineoplastic - analysis Antimetabolites, Antineoplastic - chemistry Antimetabolites, Antineoplastic - pharmacokinetics Antineoplastic agents Biological and medical sciences Calibration Chromatography, Liquid - methods Chromatography, Liquid - standards Deoxycytidine - analogs & derivatives Deoxycytidine - analysis Deoxycytidine - chemistry Deoxycytidine - pharmacokinetics dFdCTP General aspects General pharmacology Humans intra-cellular LC-MS/MS Leukocyte Count Leukocytes, Mononuclear - metabolism Medical sciences PBMCs Pharmacology. Drug treatments Proteins - analysis Reproducibility of Results Sensitivity and Specificity Tandem Mass Spectrometry - methods Tandem Mass Spectrometry - standards validation
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