Novel Cyclopropyl beta -Amino Acid Analogues of Pregabalin and Gabapentin That Target the alpha sub(2)- delta Protein

As part of a program aimed at generating compounds with affinity for the alpha sub(2)- delta subunit of voltage-gated calcium channels, several novel beta -amino acids were prepared using an efficient nitroalkane-mediated cyclopropanation as a key step. Depending on the ester that was chosen, the ta...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-04, Vol.48 (8), p.3026-3035
Hauptverfasser:	Schwarz, J B, Gibbons, SE, Graham, SR, Colbry, N L, Guzzo, PR, Le, V-D, Vartanian, M G, Kinsora, J J, Lotarski, S M, Li, Z, Dickerson, M R, Su, T-Z, Weber, M L, El-Kattan, A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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