17 beta -Oestradiol Stimulation of G-Proteins in Aged and Alzheimer's Human Brain: Comparison with Phytoestrogens

17 beta -Oestradiol Stimulation of G-Proteins in Aged and Alzheimer's Human Brain: Comparison with Phytoestrogens

The neuroprotective action of oestrogens and oestrogen-like compounds is in the focus of basic and clinical research. Although such action has been shown to be associated with neuronal plasma membranes, the implication of G-proteins remains to be elucidated. This study revealed that micromolar conce...

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Veröffentlicht in:Journal of neuroendocrinology 2008-05, Vol.20 (5), p.587-596
Hauptverfasser: Jefremov, V, Rakitin, A, Mahlapuu, R, Zilmer, K, Bogdanovic, N, Zilmer, M, Karelson, E
Format: Artikel
Sprache:eng
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Zusammenfassung:The neuroprotective action of oestrogens and oestrogen-like compounds is in the focus of basic and clinical research. Although such action has been shown to be associated with neuronal plasma membranes, the implication of G-proteins remains to be elucidated. This study revealed that micromolar concentrations ( mu m) of 17 beta -oestradiol and phytoestrogens, genistein and daidzein, significantly (P
ISSN:1365-2826
DOI:10.1111/j.1365-2826.2008.01696.x