Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality

Although it is now clear that certain Fc glycan structures on immunoglobulin G (IgG) antibodies (Abs) can have a dramatic influence on binding to selected Fcγ receptors (FcγR) and on Fc-mediated immune functions, the effects of all known Fc glycan structures still have not been exhaustively studied....

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