Pharmacodynamics of cefprozil against Haemophilus influenzae in an in vitro pharmacodynamic model

An in vitro pharmacodynamic model was used to determine the pharmacokinetic–pharmacodynamic (PK–PD) measure and magnitude most strongly related to cefprozil activity against Haemophilus influenzae. Using 3 clinical isolates of H. influenzae, a series of dose-fractionation studies were conducted, sim...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2006-12, Vol.56 (4), p.379-386
Hauptverfasser:	Smith, Patrick F., Tsuji, Brian, Booker, Brent M., Forrest, Alan, Bajic, Sanela, Kelchlin, Pamela, Bhavnani, Sujata M., Jones, Ronald N., Ambrose, Paul G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacokinetics Bacteriology Biological and medical sciences Cefprozil Cephalosporins - pharmacokinetics Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Haemophilus Haemophilus Infections - drug therapy Haemophilus Infections - microbiology Haemophilus influenzae Haemophilus influenzae - drug effects Haemophilus influenzae - growth & development Humans Infectious diseases Medical sciences Microbial Sensitivity Tests - methods Microbiology Miscellaneous Pharmacokinetics–pharmacodynamics
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