Use of an in Vitro Model of Tissue-Engineered Skin to Investigate the Mechanism of Skin Graft Contraction

Skin graft contraction leading to loss of joint mobility and cosmetic deformity remains a major clinical problem. In this study we used a tissue-engineered model of human skin, based on sterilized human adult dermis seeded with keratinocytes and fibroblasts, which contracts by up to 60% over 28 days...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Tissue engineering 2006-11, Vol.12 (11), p.3119-3133
Hauptverfasser:	Harrison, Caroline A., Gossiel, Fatma, Layton, Christopher M., Bullock, Anthony J., Johnson, Timothy, Blumsohn, Aubrey, MacNeil, Sheila
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha-Macroglobulins - pharmacology Aminopropionitrile - pharmacology Catechin - pharmacology Cell Culture Techniques Cells, Cultured Collagen Type IV - metabolism Contracture - pathology Contracture - physiopathology Cross-Linking Reagents - pharmacology Culture Media Dermis - cytology Dose-Response Relationship, Drug Estrone - pharmacology Female Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - physiology Fluorescent Antibody Technique, Indirect Glutaral - pharmacology Humans Image Processing, Computer-Assisted Immunoassay Immunohistochemistry Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - physiology Keratins - metabolism Pharmacology Photography - methods Skin Skin & tissue grafts Skin Transplantation Skin, Artificial Time Factors Tissue engineering Tissue Engineering - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!