Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice

Recently, the gastrointestinal microbiome, and its metabolites, has emerged as a potential regulator of host metabolism. However, to date little is known on the precise mechanisms of how this regulation occurs. Hydrogen sulfide (H2S) is abundantly produced in the colon by sulfate-reducing bacteria (...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2017-10, Vol.158 (10), p.3416-3425
Hauptverfasser:	Pichette, Jennifer, Fynn-Sackey, Nancy, Gagnon, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Appetite Bacteria Blood glucose Blotting, Western Cell viability Chondroitin sulfate Chondroitin Sulfates - pharmacology Colon Colon - drug effects Colon - metabolism Desulfovibrio - drug effects DNA, Bacterial - analysis Eating - drug effects Endocrinology Epithelium Feces - chemistry Food consumption Food intake Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - genetics Glucagon-Like Peptide 1 - drug effects Glucagon-Like Peptide 1 - metabolism Glucose Glucose tolerance Glucose Tolerance Test Homeostasis Hydrogen sulfide Hydrogen Sulfide - metabolism Insulin Insulin - metabolism Insulin Secretion Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Kinases Male MAP kinase Metabolism Metabolites Mice Microbiomes Microbiota Morpholines - pharmacology Organothiophosphorus Compounds - pharmacology Peptides Prebiotics Protein kinase Real-Time Polymerase Chain Reaction Regulations Rodents Secretion Sulfate reduction Sulfate-reducing bacteria Sulfates Sulfides Sulfides - pharmacology Sulfur
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