Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid
Traditional formulations of salicylic acid in ointment bases have disadvantages of being greasy and irritant due to free crystals. To explore the method for selection of oils and their ratio for topical preparation on the basis of equilibrium solubility study of salicylic acid and to evaluate temper...
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| Veröffentlicht in: | Folia Medica 2017-09, Vol.59 (3), p.279-288 |
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| creator | Ashara, Kalpesh C Shah, Ketan V |
| description | Traditional formulations of salicylic acid in ointment bases have disadvantages of being greasy and irritant due to free crystals.
To explore the method for selection of oils and their ratio for topical preparation on the basis of equilibrium solubility study of salicylic acid and to evaluate temperature effect.
Scanning and calibration curve of salicylic acid in methanol were developed. Among available oils, those that had no interference of absorbance of salicylic acid were short-listed for screening purpose. Selections of oils were carried out on the basis of equilibrium solubility study. Compatibility study was made by Fourier Transform Infra-Red spectroscopy analysis. Primitive study of oil mixtures was done. Selections of the ratio of oils were carried out on basis of constrained simplex-centroid design.
Salicylic acid had shown linearity in the range of 15-65 μg/mL in methanol at wavelength maximum (300 nm). From the equilibrium solubility study, Parker Neem® Oil (11.81 ± 0.5 mg/g), Isopropyl Myristate (11.29 ± 0.04 mg/g), Mogra Oil (9.62 ± 0.94 mg/g) were selected. The study possessed the same main Fourier transform infra-red peaks of salicylic acid in the salicylic acid-oils physical mixture. 58.64% Parker Neem® oil and 41.36% isopropyl myristate mixture was selected as optimized batch with the desirability of 0.391.
The oils mixture could be selected for topical preparation of salicylic acid like paste, cream, ointment etc. |
| doi_str_mv | 10.1515/folmed-2017-0034 |
| format | Article |
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To explore the method for selection of oils and their ratio for topical preparation on the basis of equilibrium solubility study of salicylic acid and to evaluate temperature effect.
Scanning and calibration curve of salicylic acid in methanol were developed. Among available oils, those that had no interference of absorbance of salicylic acid were short-listed for screening purpose. Selections of oils were carried out on the basis of equilibrium solubility study. Compatibility study was made by Fourier Transform Infra-Red spectroscopy analysis. Primitive study of oil mixtures was done. Selections of the ratio of oils were carried out on basis of constrained simplex-centroid design.
Salicylic acid had shown linearity in the range of 15-65 μg/mL in methanol at wavelength maximum (300 nm). From the equilibrium solubility study, Parker Neem® Oil (11.81 ± 0.5 mg/g), Isopropyl Myristate (11.29 ± 0.04 mg/g), Mogra Oil (9.62 ± 0.94 mg/g) were selected. The study possessed the same main Fourier transform infra-red peaks of salicylic acid in the salicylic acid-oils physical mixture. 58.64% Parker Neem® oil and 41.36% isopropyl myristate mixture was selected as optimized batch with the desirability of 0.391.
The oils mixture could be selected for topical preparation of salicylic acid like paste, cream, ointment etc.</description><identifier>ISSN: 0204-8043</identifier><identifier>ISSN: 1314-2143</identifier><identifier>EISSN: 1314-2143</identifier><identifier>DOI: 10.1515/folmed-2017-0034</identifier><identifier>PMID: 28976900</identifier><language>eng</language><publisher>Bulgaria: MEDICAL UNIVERSITY- PLOVDIV</publisher><subject>Administration, Topical ; Drug Compounding - methods ; Drug delivery systems ; Drug Stability ; Equilibrium ; F-test ; Fungal infections ; Humans ; keratolytic agent ; Methanol - chemistry ; Microemulsions ; Nanoparticles ; Neem oil ; Oils - chemistry ; salicylic acid ; Salicylic Acid - pharmacology ; Skin diseases ; Solubility ; Student’s t-test ; Temperature ; Temperature effects ; unpaired</subject><ispartof>Folia Medica, 2017-09, Vol.59 (3), p.279-288</ispartof><rights>Copyright MEDICAL UNIVERSITY- PLOVDIV 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4059-6a27b9dc4d662ab92e8a6b2dacc14b1cabde881ac399be09e14fedb8f604df2d3</citedby><cites>FETCH-LOGICAL-c4059-6a27b9dc4d662ab92e8a6b2dacc14b1cabde881ac399be09e14fedb8f604df2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28976900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashara, Kalpesh C</creatorcontrib><creatorcontrib>Shah, Ketan V</creatorcontrib><title>Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid</title><title>Folia Medica</title><addtitle>Folia Med (Plovdiv)</addtitle><description>Traditional formulations of salicylic acid in ointment bases have disadvantages of being greasy and irritant due to free crystals.
To explore the method for selection of oils and their ratio for topical preparation on the basis of equilibrium solubility study of salicylic acid and to evaluate temperature effect.
Scanning and calibration curve of salicylic acid in methanol were developed. Among available oils, those that had no interference of absorbance of salicylic acid were short-listed for screening purpose. Selections of oils were carried out on the basis of equilibrium solubility study. Compatibility study was made by Fourier Transform Infra-Red spectroscopy analysis. Primitive study of oil mixtures was done. Selections of the ratio of oils were carried out on basis of constrained simplex-centroid design.
Salicylic acid had shown linearity in the range of 15-65 μg/mL in methanol at wavelength maximum (300 nm). From the equilibrium solubility study, Parker Neem® Oil (11.81 ± 0.5 mg/g), Isopropyl Myristate (11.29 ± 0.04 mg/g), Mogra Oil (9.62 ± 0.94 mg/g) were selected. The study possessed the same main Fourier transform infra-red peaks of salicylic acid in the salicylic acid-oils physical mixture. 58.64% Parker Neem® oil and 41.36% isopropyl myristate mixture was selected as optimized batch with the desirability of 0.391.
The oils mixture could be selected for topical preparation of salicylic acid like paste, cream, ointment etc.</description><subject>Administration, Topical</subject><subject>Drug Compounding - methods</subject><subject>Drug delivery systems</subject><subject>Drug Stability</subject><subject>Equilibrium</subject><subject>F-test</subject><subject>Fungal infections</subject><subject>Humans</subject><subject>keratolytic agent</subject><subject>Methanol - chemistry</subject><subject>Microemulsions</subject><subject>Nanoparticles</subject><subject>Neem oil</subject><subject>Oils - chemistry</subject><subject>salicylic acid</subject><subject>Salicylic Acid - pharmacology</subject><subject>Skin diseases</subject><subject>Solubility</subject><subject>Student’s t-test</subject><subject>Temperature</subject><subject>Temperature effects</subject><subject>unpaired</subject><issn>0204-8043</issn><issn>1314-2143</issn><issn>1314-2143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNpdkb1vFDEQxS1ERI5AT4VWoqFZMv5Yr12GKJBIEReJo7b8iXzyrRf7tsh_H99dQpHCGuvNb57Hegh9wvAND3i4DDntvOsJ4LEHoOwNWmGKWU8wo2_RCgiwXgCj5-h9rVsAPgAM79A5EXLkEmCF1r-Wfe305LrvObVbDt06pqOw8bvZF71fiu_i1G3yHK1O3UPxs25yzNMR_61TtI_tdFc2ug_oLOhU_cfneoH-_LjZXN_29-ufd9dX971lMMieazIa6SxznBNtJPFCc0OcthYzg602zguBtaVSGg_SYxa8MyJwYC4QRy_Q3cnXZb1Vc4k7XR5V1lEdhVz-Kl320SavHMHEjyIw4jwDCQaLQIkdAne0PTI0r68nr7nkf4uve7WL1fqU9OTzUhWWbOR4bHs39MsrdJuXMrWfNmoUg-SS0UbBibIl11p8-L8gBnUITp2CU4fg1CG4NvL52Xgxh87LwEtS9AniR5P8</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Ashara, Kalpesh C</creator><creator>Shah, Ketan V</creator><general>MEDICAL UNIVERSITY- PLOVDIV</general><general>Pensoft Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20170901</creationdate><title>Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid</title><author>Ashara, Kalpesh C ; Shah, Ketan V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4059-6a27b9dc4d662ab92e8a6b2dacc14b1cabde881ac399be09e14fedb8f604df2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Topical</topic><topic>Drug Compounding - methods</topic><topic>Drug delivery systems</topic><topic>Drug Stability</topic><topic>Equilibrium</topic><topic>F-test</topic><topic>Fungal infections</topic><topic>Humans</topic><topic>keratolytic agent</topic><topic>Methanol - chemistry</topic><topic>Microemulsions</topic><topic>Nanoparticles</topic><topic>Neem oil</topic><topic>Oils - chemistry</topic><topic>salicylic acid</topic><topic>Salicylic Acid - pharmacology</topic><topic>Skin diseases</topic><topic>Solubility</topic><topic>Student’s t-test</topic><topic>Temperature</topic><topic>Temperature effects</topic><topic>unpaired</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashara, Kalpesh C</creatorcontrib><creatorcontrib>Shah, Ketan V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Folia Medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashara, Kalpesh C</au><au>Shah, Ketan V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid</atitle><jtitle>Folia Medica</jtitle><addtitle>Folia Med (Plovdiv)</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>59</volume><issue>3</issue><spage>279</spage><epage>288</epage><pages>279-288</pages><issn>0204-8043</issn><issn>1314-2143</issn><eissn>1314-2143</eissn><abstract>Traditional formulations of salicylic acid in ointment bases have disadvantages of being greasy and irritant due to free crystals.
To explore the method for selection of oils and their ratio for topical preparation on the basis of equilibrium solubility study of salicylic acid and to evaluate temperature effect.
Scanning and calibration curve of salicylic acid in methanol were developed. Among available oils, those that had no interference of absorbance of salicylic acid were short-listed for screening purpose. Selections of oils were carried out on the basis of equilibrium solubility study. Compatibility study was made by Fourier Transform Infra-Red spectroscopy analysis. Primitive study of oil mixtures was done. Selections of the ratio of oils were carried out on basis of constrained simplex-centroid design.
Salicylic acid had shown linearity in the range of 15-65 μg/mL in methanol at wavelength maximum (300 nm). From the equilibrium solubility study, Parker Neem® Oil (11.81 ± 0.5 mg/g), Isopropyl Myristate (11.29 ± 0.04 mg/g), Mogra Oil (9.62 ± 0.94 mg/g) were selected. The study possessed the same main Fourier transform infra-red peaks of salicylic acid in the salicylic acid-oils physical mixture. 58.64% Parker Neem® oil and 41.36% isopropyl myristate mixture was selected as optimized batch with the desirability of 0.391.
The oils mixture could be selected for topical preparation of salicylic acid like paste, cream, ointment etc.</abstract><cop>Bulgaria</cop><pub>MEDICAL UNIVERSITY- PLOVDIV</pub><pmid>28976900</pmid><doi>10.1515/folmed-2017-0034</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Topical Drug Compounding - methods Drug delivery systems Drug Stability Equilibrium F-test Fungal infections Humans keratolytic agent Methanol - chemistry Microemulsions Nanoparticles Neem oil Oils - chemistry salicylic acid Salicylic Acid - pharmacology Skin diseases Solubility Student’s t-test Temperature Temperature effects unpaired |
| title | Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid |
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