Posterior Insular GABA Levels Inversely Correlate with the Intensity of Experimental Mechanical Pain in Healthy Subjects

•Excitatory and inhibitory neurotransmitter concentrations in the posterior insula are related to individual pain sensitivity.•Pinprick pain ratings inversely correlate with GABA levels in the posterior insula.•Pinprick pain ratings correlate positively with glutamate levels in the posterior insula....

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Veröffentlicht in:	Neuroscience 2018-09, Vol.387, p.116-122
Hauptverfasser:	Thiaucourt, Margot, Shabes, Polina, Schloss, Natalie, Sack, Markus, Baumgärtner, Ulf, Schmahl, Christian, Ende, Gabriele
Format:	Artikel
Sprache:	eng
Schlagworte:	Cerebral Cortex - metabolism Female GABA gamma-Aminobutyric Acid - metabolism glutamate Glutamic Acid - metabolism Healthy Volunteers Humans Magnetic Resonance Spectroscopy pain Pain Threshold - physiology pinprick posterior insula spectroscopy Young Adult
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