Synthesis of Novel Rhinacanthins and Related Anticancer Naphthoquinone Esters

Rhinacanthin-M, -N and -Q, natural products isolated from the medicinal plant Rhinacanthus nasutus, and 39 novel naphthoquinone esters have been synthesized in excellent yield by esterification of naphthoquinone-3-(propan-3‘-ols) with benzoic or naphthoic acids. Almost all the naphthoquinone esters...

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Veröffentlicht in:	Journal of medicinal chemistry 2004-08, Vol.47 (18), p.4427-4438
Hauptverfasser:	Kongkathip, Ngampong, Luangkamin, Suwaporn, Kongkathip, Boonsong, Sangma, Chak, Grigg, Ronald, Kongsaeree, Palangpon, Prabpai, Samran, Pradidphol, Narathip, Piyaviriyagul, Suratsawadee, Siripong, Pongpun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Binding Sites Biological and medical sciences Cell Division - drug effects Cell Line, Tumor Doxorubicin - chemistry Esters - chemical synthesis Esters - pharmacology General aspects General pharmacology Humans Inhibitory Concentration 50 Medical sciences Models, Molecular Naphthoquinones - chemical synthesis Naphthoquinones - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rhinacanthus nasutus Structure-Activity Relationship Topoisomerase II Inhibitors
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