Supercritical fluid-micronized ipratropium bromide for pulmonary drug delivery
Ipratropium bromide (IB) was micronized by means of a CO 2-based aerosol solvent extraction system (ASES) in order to improve the particle shape and size characteristics for use in inhalation therapy. The particle size parameter most relevant to pulmonary delivery is the aerodynamic diameter. In thi...
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| Veröffentlicht in: | Powder technology 2008-02, Vol.182 (1), p.25-32 |
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| creator | Kim, Yong Ho Shing, Katherine S. |
| description | Ipratropium bromide (IB) was micronized by means of a CO
2-based aerosol solvent extraction system (ASES) in order to improve the particle shape and size characteristics for use in inhalation therapy. The particle size parameter most relevant to pulmonary delivery is the aerodynamic diameter. In this study, ASES experiments were conducted using various liquid solvents for IB such as dimethylformamide (DMF), ethanol (EtOH), and mixtures of ethanol and acetone (EtOH/Ac). Several operating parameters were varied including temperature, pressure, IB concentration in the liquid solution, and the solution injection rate. The particles were analyzed by scanning electron microscopy (SEM). The true density of the particles was measured using a pycnometer and the mass median aerodynamic diameter (MMAD) determined. The results indicate that the size and morphology of the microparticles are most sensitive to solvent choice. Optimum results were obtained when IB particles were precipitated from DMF. The particles were more regular in shape, slightly elliptical, not agglomerated, and within the aerodynamic diameter range of 0.6–3.0 μm. Fourier transform infrared (FTIR) studies indicate no structural deformation as result of the ASES process. The regional depositions of inhaled IB particles were estimated using a multiple-path model of particle deposition (MPPD). The results indicate that IB particles with MMAD in the range of 2–3 μm deposited mainly in the respiratory airways in the lung.
Ipratropium bromide was micronized by means of a CO
2-based aerosol solvent extraction system. The particles precipitated from DMF were of regular shape, slightly elliptical, not agglomerated and within the aerodynamic diameter range of 0.6–3.0 μm which is suitable for pulmonary delivery. The regional depositions of inhaled ipratropium bromide particles were estimated using a multiple-path model of particle deposition.
[Display omitted] |
| doi_str_mv | 10.1016/j.powtec.2007.04.009 |
| format | Article |
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2-based aerosol solvent extraction system (ASES) in order to improve the particle shape and size characteristics for use in inhalation therapy. The particle size parameter most relevant to pulmonary delivery is the aerodynamic diameter. In this study, ASES experiments were conducted using various liquid solvents for IB such as dimethylformamide (DMF), ethanol (EtOH), and mixtures of ethanol and acetone (EtOH/Ac). Several operating parameters were varied including temperature, pressure, IB concentration in the liquid solution, and the solution injection rate. The particles were analyzed by scanning electron microscopy (SEM). The true density of the particles was measured using a pycnometer and the mass median aerodynamic diameter (MMAD) determined. The results indicate that the size and morphology of the microparticles are most sensitive to solvent choice. Optimum results were obtained when IB particles were precipitated from DMF. The particles were more regular in shape, slightly elliptical, not agglomerated, and within the aerodynamic diameter range of 0.6–3.0 μm. Fourier transform infrared (FTIR) studies indicate no structural deformation as result of the ASES process. The regional depositions of inhaled IB particles were estimated using a multiple-path model of particle deposition (MPPD). The results indicate that IB particles with MMAD in the range of 2–3 μm deposited mainly in the respiratory airways in the lung.
Ipratropium bromide was micronized by means of a CO
2-based aerosol solvent extraction system. The particles precipitated from DMF were of regular shape, slightly elliptical, not agglomerated and within the aerodynamic diameter range of 0.6–3.0 μm which is suitable for pulmonary delivery. The regional depositions of inhaled ipratropium bromide particles were estimated using a multiple-path model of particle deposition.
[Display omitted]</description><identifier>ISSN: 0032-5910</identifier><identifier>EISSN: 1873-328X</identifier><identifier>DOI: 10.1016/j.powtec.2007.04.009</identifier><identifier>CODEN: POTEBX</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Aerodynamic diameter ; Aerosol solvent extraction system ; Applied sciences ; Chemical engineering ; Exact sciences and technology ; Ipratropium bromide ; Liquid-liquid extraction ; Miscellaneous ; Pulmonary delivery ; Solid-solid systems ; Supercritical antisolvent</subject><ispartof>Powder technology, 2008-02, Vol.182 (1), p.25-32</ispartof><rights>2007</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-56287b8ee498d8c06d6010b25db6c62d4ac806e8749e5634a6f32d86f951884c3</citedby><cites>FETCH-LOGICAL-c367t-56287b8ee498d8c06d6010b25db6c62d4ac806e8749e5634a6f32d86f951884c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0032591007002264$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20068885$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Yong Ho</creatorcontrib><creatorcontrib>Shing, Katherine S.</creatorcontrib><title>Supercritical fluid-micronized ipratropium bromide for pulmonary drug delivery</title><title>Powder technology</title><description>Ipratropium bromide (IB) was micronized by means of a CO
2-based aerosol solvent extraction system (ASES) in order to improve the particle shape and size characteristics for use in inhalation therapy. The particle size parameter most relevant to pulmonary delivery is the aerodynamic diameter. In this study, ASES experiments were conducted using various liquid solvents for IB such as dimethylformamide (DMF), ethanol (EtOH), and mixtures of ethanol and acetone (EtOH/Ac). Several operating parameters were varied including temperature, pressure, IB concentration in the liquid solution, and the solution injection rate. The particles were analyzed by scanning electron microscopy (SEM). The true density of the particles was measured using a pycnometer and the mass median aerodynamic diameter (MMAD) determined. The results indicate that the size and morphology of the microparticles are most sensitive to solvent choice. Optimum results were obtained when IB particles were precipitated from DMF. The particles were more regular in shape, slightly elliptical, not agglomerated, and within the aerodynamic diameter range of 0.6–3.0 μm. Fourier transform infrared (FTIR) studies indicate no structural deformation as result of the ASES process. The regional depositions of inhaled IB particles were estimated using a multiple-path model of particle deposition (MPPD). The results indicate that IB particles with MMAD in the range of 2–3 μm deposited mainly in the respiratory airways in the lung.
Ipratropium bromide was micronized by means of a CO
2-based aerosol solvent extraction system. The particles precipitated from DMF were of regular shape, slightly elliptical, not agglomerated and within the aerodynamic diameter range of 0.6–3.0 μm which is suitable for pulmonary delivery. The regional depositions of inhaled ipratropium bromide particles were estimated using a multiple-path model of particle deposition.
[Display omitted]</description><subject>Aerodynamic diameter</subject><subject>Aerosol solvent extraction system</subject><subject>Applied sciences</subject><subject>Chemical engineering</subject><subject>Exact sciences and technology</subject><subject>Ipratropium bromide</subject><subject>Liquid-liquid extraction</subject><subject>Miscellaneous</subject><subject>Pulmonary delivery</subject><subject>Solid-solid systems</subject><subject>Supercritical antisolvent</subject><issn>0032-5910</issn><issn>1873-328X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EEqXwDxiywJZwThzHWZBQxZdUwQBIbJZrX5CrJA52UlR-PUatGJlued737h5CzilkFCi_WmeD-xpRZzlAlQHLAOoDMqOiKtIiF--HZAZQ5GlZUzgmJyGsAYAXFGbk6WUa0GtvR6tVmzTtZE3aWe1db7_RJHbwavRusFOXrLzrrMGkcT4ZprZzvfLbxPjpIzHY2g367Sk5alQb8Gw_5-Tt7vZ18ZAun-8fFzfLVBe8GtOS56JaCURWCyM0cMOBwiovzYprnhumtACOomI1lrxgijdFbgRv6pIKwXQxJ5e73sG7zwnDKDsbNLat6tFNQdKaVQxEHUG2A-NHIXhs5OBtF--WFOSvPLmWO3nyV54EJqO8GLvY96sQvTRe9dqGv2xEuRCijNz1jsP47Mail0Fb7DUa61GP0jj7_6Ifb-uIVg</recordid><startdate>20080215</startdate><enddate>20080215</enddate><creator>Kim, Yong Ho</creator><creator>Shing, Katherine S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20080215</creationdate><title>Supercritical fluid-micronized ipratropium bromide for pulmonary drug delivery</title><author>Kim, Yong Ho ; Shing, Katherine S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-56287b8ee498d8c06d6010b25db6c62d4ac806e8749e5634a6f32d86f951884c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aerodynamic diameter</topic><topic>Aerosol solvent extraction system</topic><topic>Applied sciences</topic><topic>Chemical engineering</topic><topic>Exact sciences and technology</topic><topic>Ipratropium bromide</topic><topic>Liquid-liquid extraction</topic><topic>Miscellaneous</topic><topic>Pulmonary delivery</topic><topic>Solid-solid systems</topic><topic>Supercritical antisolvent</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Yong Ho</creatorcontrib><creatorcontrib>Shing, Katherine S.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Powder technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Yong Ho</au><au>Shing, Katherine S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supercritical fluid-micronized ipratropium bromide for pulmonary drug delivery</atitle><jtitle>Powder technology</jtitle><date>2008-02-15</date><risdate>2008</risdate><volume>182</volume><issue>1</issue><spage>25</spage><epage>32</epage><pages>25-32</pages><issn>0032-5910</issn><eissn>1873-328X</eissn><coden>POTEBX</coden><abstract>Ipratropium bromide (IB) was micronized by means of a CO
2-based aerosol solvent extraction system (ASES) in order to improve the particle shape and size characteristics for use in inhalation therapy. The particle size parameter most relevant to pulmonary delivery is the aerodynamic diameter. In this study, ASES experiments were conducted using various liquid solvents for IB such as dimethylformamide (DMF), ethanol (EtOH), and mixtures of ethanol and acetone (EtOH/Ac). Several operating parameters were varied including temperature, pressure, IB concentration in the liquid solution, and the solution injection rate. The particles were analyzed by scanning electron microscopy (SEM). The true density of the particles was measured using a pycnometer and the mass median aerodynamic diameter (MMAD) determined. The results indicate that the size and morphology of the microparticles are most sensitive to solvent choice. Optimum results were obtained when IB particles were precipitated from DMF. The particles were more regular in shape, slightly elliptical, not agglomerated, and within the aerodynamic diameter range of 0.6–3.0 μm. Fourier transform infrared (FTIR) studies indicate no structural deformation as result of the ASES process. The regional depositions of inhaled IB particles were estimated using a multiple-path model of particle deposition (MPPD). The results indicate that IB particles with MMAD in the range of 2–3 μm deposited mainly in the respiratory airways in the lung.
Ipratropium bromide was micronized by means of a CO
2-based aerosol solvent extraction system. The particles precipitated from DMF were of regular shape, slightly elliptical, not agglomerated and within the aerodynamic diameter range of 0.6–3.0 μm which is suitable for pulmonary delivery. The regional depositions of inhaled ipratropium bromide particles were estimated using a multiple-path model of particle deposition.
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| source | Elsevier ScienceDirect Journals |
| subjects | Aerodynamic diameter Aerosol solvent extraction system Applied sciences Chemical engineering Exact sciences and technology Ipratropium bromide Liquid-liquid extraction Miscellaneous Pulmonary delivery Solid-solid systems Supercritical antisolvent |
| title | Supercritical fluid-micronized ipratropium bromide for pulmonary drug delivery |
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