Telomere-Driven Karyotypic Complexity Concurs with p16 super(INK4a) Inactivation in TP53-Competent Immortal Endothelial Cells

Critically short telomeres promote chromosomal fusions, which in TP53-defective cells initiate the formation of cytogenetic aberrations that are typical of human cancer cells. Expression of the enzyme telomerase stabilizes normal and aberrant chromosomes by maintaining telomere length. However, prev...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-11, Vol.66 (22), p.10691-10700
Hauptverfasser:	Wen, Victoria W, Wu, Kaida, Baksh, Sheik, Hinshelwood, Rebecca A, Lock, Richard B, Clark, Susan J, Moore, Malcolm AS, MacKenzie, Karen L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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