The Potential of Gelam Honey in Promoting the Proliferative Phase of Corneal Reepithelialization
Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden. This is a retrospective chart re...
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| Veröffentlicht in: | Wounds (King of Prussia, Pa.) Pa.), 2017-12, Vol.29 (12), p.380-386 |
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| container_title | Wounds (King of Prussia, Pa.) |
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| creator | Zarick, Caitlin S Benkert, Elizabeth A Oliver, Noah G Steinberg, John S Evans, Karen K Attinger, Christopher E Rocha, Zinnia M Kim, Paul J |
| description | Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden.
This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy.
All patients in the study were treated with a topical gel along with standard of care modalities.
A total of 48 patients with 76 wounds (50/76 venous leg ulcers; 65.8%) were identi ed and analyzed. Of the 48 patients, 11 (22.9%) had complete wound closure at a mean of 101.6 days of treatment. The number of wounds decreasing in size improved from 45.3% to 77.6% after gel therapy. An analysis of all wounds showed an increase in size by 0.7% weekly with the topical gel; how- ever, a mean weekly healing rate of 6.5% was seen when analyzing only the subset of wounds that decreased in size.
Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low. |
| format | Article |
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This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy.
All patients in the study were treated with a topical gel along with standard of care modalities.
A total of 48 patients with 76 wounds (50/76 venous leg ulcers; 65.8%) were identi ed and analyzed. Of the 48 patients, 11 (22.9%) had complete wound closure at a mean of 101.6 days of treatment. The number of wounds decreasing in size improved from 45.3% to 77.6% after gel therapy. An analysis of all wounds showed an increase in size by 0.7% weekly with the topical gel; how- ever, a mean weekly healing rate of 6.5% was seen when analyzing only the subset of wounds that decreased in size.
Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low.</description><identifier>EISSN: 1943-2704</identifier><identifier>PMID: 28976341</identifier><language>eng</language><publisher>United States</publisher><subject>Anti-Infective Agents - pharmacology ; Cell Proliferation - drug effects ; Cell Proliferation - physiology ; Epithelium, Corneal - drug effects ; Epithelium, Corneal - injuries ; Epithelium, Corneal - pathology ; Female ; Gene Expression ; Honey ; Humans ; Male ; Organ Culture Techniques ; Re-Epithelialization - drug effects ; Re-Epithelialization - physiology ; Retrospective Studies ; Treatment Outcome ; Wound Healing - physiology</subject><ispartof>Wounds (King of Prussia, Pa.), 2017-12, Vol.29 (12), p.380-386</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28976341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zarick, Caitlin S</creatorcontrib><creatorcontrib>Benkert, Elizabeth A</creatorcontrib><creatorcontrib>Oliver, Noah G</creatorcontrib><creatorcontrib>Steinberg, John S</creatorcontrib><creatorcontrib>Evans, Karen K</creatorcontrib><creatorcontrib>Attinger, Christopher E</creatorcontrib><creatorcontrib>Rocha, Zinnia M</creatorcontrib><creatorcontrib>Kim, Paul J</creatorcontrib><title>The Potential of Gelam Honey in Promoting the Proliferative Phase of Corneal Reepithelialization</title><title>Wounds (King of Prussia, Pa.)</title><addtitle>Wounds</addtitle><description>Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden.
This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy.
All patients in the study were treated with a topical gel along with standard of care modalities.
A total of 48 patients with 76 wounds (50/76 venous leg ulcers; 65.8%) were identi ed and analyzed. Of the 48 patients, 11 (22.9%) had complete wound closure at a mean of 101.6 days of treatment. The number of wounds decreasing in size improved from 45.3% to 77.6% after gel therapy. An analysis of all wounds showed an increase in size by 0.7% weekly with the topical gel; how- ever, a mean weekly healing rate of 6.5% was seen when analyzing only the subset of wounds that decreased in size.
Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low.</description><subject>Anti-Infective Agents - pharmacology</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Proliferation - physiology</subject><subject>Epithelium, Corneal - drug effects</subject><subject>Epithelium, Corneal - injuries</subject><subject>Epithelium, Corneal - pathology</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Honey</subject><subject>Humans</subject><subject>Male</subject><subject>Organ Culture Techniques</subject><subject>Re-Epithelialization - drug effects</subject><subject>Re-Epithelialization - physiology</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Wound Healing - physiology</subject><issn>1943-2704</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LAzEYhIMgtlb_guToZSHZfG2OUrQVChap5zXNvmsj2c2a7Ar115tiPc0MPDOHuUBzqjkrSkX4DF2n9EkIE4SRKzQrK60k43SO3ncHwNswQj8643Fo8Qq86fA69HDErsfbGLowuv4DjycyBu9aiGZ03zkdTIJTZxliD7n-CjC4zPm85X4yFPobdNkan-D2rAv09vS4W66LzcvqefmwKQZayrGwvKVSiwb2TcUFVyBUZUVZSW6z1URSaUHtjW1IKTnTVjVQUa4Y5dAIAmyB7v92hxi-Jkhj3blkwXvTQ5hSnb9QRGuhyozendFp30FTD9F1Jh7r_1fYL7lhXWs</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Zarick, Caitlin S</creator><creator>Benkert, Elizabeth A</creator><creator>Oliver, Noah G</creator><creator>Steinberg, John S</creator><creator>Evans, Karen K</creator><creator>Attinger, Christopher E</creator><creator>Rocha, Zinnia M</creator><creator>Kim, Paul J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201712</creationdate><title>The Potential of Gelam Honey in Promoting the Proliferative Phase of Corneal Reepithelialization</title><author>Zarick, Caitlin S ; Benkert, Elizabeth A ; Oliver, Noah G ; Steinberg, John S ; Evans, Karen K ; Attinger, Christopher E ; Rocha, Zinnia M ; Kim, Paul J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-c4f1695debd84547e578c52864ce5790616ce7bacd026439c7de8147314ed50e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anti-Infective Agents - pharmacology</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Proliferation - physiology</topic><topic>Epithelium, Corneal - drug effects</topic><topic>Epithelium, Corneal - injuries</topic><topic>Epithelium, Corneal - pathology</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Honey</topic><topic>Humans</topic><topic>Male</topic><topic>Organ Culture Techniques</topic><topic>Re-Epithelialization - drug effects</topic><topic>Re-Epithelialization - physiology</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zarick, Caitlin S</creatorcontrib><creatorcontrib>Benkert, Elizabeth A</creatorcontrib><creatorcontrib>Oliver, Noah G</creatorcontrib><creatorcontrib>Steinberg, John S</creatorcontrib><creatorcontrib>Evans, Karen K</creatorcontrib><creatorcontrib>Attinger, Christopher E</creatorcontrib><creatorcontrib>Rocha, Zinnia M</creatorcontrib><creatorcontrib>Kim, Paul J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Wounds (King of Prussia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zarick, Caitlin S</au><au>Benkert, Elizabeth A</au><au>Oliver, Noah G</au><au>Steinberg, John S</au><au>Evans, Karen K</au><au>Attinger, Christopher E</au><au>Rocha, Zinnia M</au><au>Kim, Paul J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Potential of Gelam Honey in Promoting the Proliferative Phase of Corneal Reepithelialization</atitle><jtitle>Wounds (King of Prussia, Pa.)</jtitle><addtitle>Wounds</addtitle><date>2017-12</date><risdate>2017</risdate><volume>29</volume><issue>12</issue><spage>380</spage><epage>386</epage><pages>380-386</pages><eissn>1943-2704</eissn><abstract>Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden.
This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy.
All patients in the study were treated with a topical gel along with standard of care modalities.
A total of 48 patients with 76 wounds (50/76 venous leg ulcers; 65.8%) were identi ed and analyzed. Of the 48 patients, 11 (22.9%) had complete wound closure at a mean of 101.6 days of treatment. The number of wounds decreasing in size improved from 45.3% to 77.6% after gel therapy. An analysis of all wounds showed an increase in size by 0.7% weekly with the topical gel; how- ever, a mean weekly healing rate of 6.5% was seen when analyzing only the subset of wounds that decreased in size.
Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low.</abstract><cop>United States</cop><pmid>28976341</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Wounds (King of Prussia, Pa.), 2017-12, Vol.29 (12), p.380-386 |
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| language | eng |
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| subjects | Anti-Infective Agents - pharmacology Cell Proliferation - drug effects Cell Proliferation - physiology Epithelium, Corneal - drug effects Epithelium, Corneal - injuries Epithelium, Corneal - pathology Female Gene Expression Honey Humans Male Organ Culture Techniques Re-Epithelialization - drug effects Re-Epithelialization - physiology Retrospective Studies Treatment Outcome Wound Healing - physiology |
| title | The Potential of Gelam Honey in Promoting the Proliferative Phase of Corneal Reepithelialization |
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