Impact of the Commercialization of Three Generic Angiotensin II Receptor Blockers on Adverse Events in Quebec, Canada: A Population-Based Time Series Analysis

Once the patent of a brand-name drug expires, generic drugs are commercialized, and substitution from brand-name to generics may occur. Generic drug equivalence is evaluated through comparative bioavailability studies. Few studies have assessed outcomes after generic drug commercialization at a popu...

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Veröffentlicht in:	Circulation Cardiovascular quality and outcomes 2017-10, Vol.10 (10)
Hauptverfasser:	Leclerc, Jacinthe, Blais, Claudia, Rochette, Louis, Hamel, Denis, Guénette, Line, Poirier, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Receptor Antagonists - adverse effects Angiotensin Receptor Antagonists - economics Angiotensin Receptor Antagonists - therapeutic use Antihypertensive Agents - adverse effects Antihypertensive Agents - economics Antihypertensive Agents - therapeutic use Benzimidazoles - adverse effects Benzimidazoles - economics Benzimidazoles - therapeutic use Databases, Factual Drug Costs Drug Substitution - adverse effects Drug Substitution - economics Drugs, Generic - adverse effects Drugs, Generic - economics Drugs, Generic - therapeutic use Emergency Service, Hospital Humans Hypertension - diagnosis Hypertension - drug therapy Hypertension - economics Hypertension - mortality Losartan - adverse effects Losartan - economics Losartan - therapeutic use Patient Admission Patient Safety Population Surveillance Quebec - epidemiology Referral and Consultation Retrospective Studies Risk Factors Tetrazoles - adverse effects Tetrazoles - economics Tetrazoles - therapeutic use Therapeutic Equivalency Time Factors Treatment Outcome Valsartan - adverse effects Valsartan - economics Valsartan - therapeutic use
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