Autotemplate Microcapsules of CaCO3/Pectin and Nonstoichiometric Complexes as Sustained Tetracycline Hydrochloride Delivery Carriers

Autotemplate Microcapsules of CaCO3/Pectin and Nonstoichiometric Complexes as Sustained Tetracycline Hydrochloride Delivery Carriers

New types of composites were obtained by an autotemplate method for assembling hollow CaCO3 capsules by using pH-sensitive polymers. Five pectin samples, which differ in the methylation degree and/or amide content, and some nonstoichiometric polyelectrolyte complex dispersions, prepared with the pec...

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Veröffentlicht in:ACS applied materials & interfaces 2017-10, Vol.9 (42), p.37264-37278
Hauptverfasser: Mihai, Marcela, Racovita, Stefania, Vasiliu, Ana-Lavinia, Doroftei, Florica, Barbu-Mic, Cristian, Schwarz, Simona, Steinbach, Christine, Simon, Frank
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container_end_page 37278
container_issue 42
container_start_page 37264
container_title ACS applied materials & interfaces
container_volume 9
creator Mihai, Marcela
Racovita, Stefania
Vasiliu, Ana-Lavinia
Doroftei, Florica
Barbu-Mic, Cristian
Schwarz, Simona
Steinbach, Christine
Simon, Frank
description New types of composites were obtained by an autotemplate method for assembling hollow CaCO3 capsules by using pH-sensitive polymers. Five pectin samples, which differ in the methylation degree and/or amide content, and some nonstoichiometric polyelectrolyte complex dispersions, prepared with the pectin samples and poly­(allylamine hydrochloride), were used to control the crystal growth. The morphology of the composites was investigated by scanning electron microscopy, and the polymorphs characteristics were investigated by FTIR spectroscopy. The presence of the polymer in the composite particles was evidenced by X-ray photoelectron spectroscopy, particle charge density, and zeta-potential. The new CaCO3/pectin hollow capsules were tested as a possible matrix for a tetracycline hydrochloride carrier. The kinetics of the drug release mechanism was followed using Higuchi and Korsmeyer–Peppas mathematical models.
doi_str_mv 10.1021/acsami.7b09333
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title Autotemplate Microcapsules of CaCO3/Pectin and Nonstoichiometric Complexes as Sustained Tetracycline Hydrochloride Delivery Carriers
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