Diazoxide prevents H2O2-induced chondrocyte apoptosis and cartilage degeneration in a rat model of osteoarthritis by reducing endoplasmic reticulum stress

Osteoarthritis (OA) is a common disease affecting elderly individuals. Its incidence rises sharply with age, and chondrocyte apoptosis plays a vital role in its pathogenesis. Diazoxide opens mitochondrial ATP-sensitive potassium (mitoKATP) channels and exerts multiple pharmacological effects, includ...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-11, Vol.95, p.1886-1894
Hauptverfasser:	Gu, YunTao, Chen, Jian, Meng, ZhuLong, Yao, JiangLing, Ge, WanYu, Chen, KeWei, Cheng, ShaoWen, Fu, Jian, Peng, Lei, Zhao, YingZheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptotic Chondrocyte Diazoxide Endoplasmic reticulum stress (ERS) Osteoarthritis (OA)
Online-Zugang:	Volltext
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