ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice

Streptococcus (S.) pneumoniae is the most common cause of community‐acquired pneumonia. The Nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome, consisting of NLRP3, ASC (the adaptor apoptosis‐associated speck‐like protein containing a CARD) and caspase‐1, has been implicated in...

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Veröffentlicht in:	European journal of immunology 2018-01, Vol.48 (1), p.66-79
Hauptverfasser:	Lieshout, Miriam H.P., Vos, Alex F., Dessing, Mark C., Porto, Alexander P.N.A., Boer, Onno J., Beer, Regina, Terpstra, Sanne, Florquin, Sandrine, van't Veer, Cornelis, der Poll, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bacteria Bacterial infection Caspase Caspase-1 Immune response Inflammasome Inflammasomes Mice MyD88 MyD88 protein Pneumonia Pyrin protein Respiratory tract Rodents Streptococcus infections Streptococcus pneumoniae TLR2 protein TLR4 protein Toll-like receptors
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