Sanguinarine inhibits pancreatic cancer stem cell characteristics by inducing oxidative stress and suppressing sonic hedgehog-Gli-Nanog pathway

Sonic hedgehog pathway is highly activated in pancreatic cancer stem cells (CSC) which play crucial roles in cancer initiation, progression and metastasis. However, the molecular mechanisms by which sanguinarine regulates pancreatic CSC characteristics is not well understood. The objectives of this...

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Veröffentlicht in:	Carcinogenesis (New York) 2017-10, Vol.38 (10), p.1047-1056
Hauptverfasser:	Ma, Yiming, Yu, Wei, Shrivastava, Anju, Alemi, Farzad, Lankachandra, Kamani, Srivastava, Rakesh K, Shankar, Sharmila
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Benzophenanthridines - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Epithelial-Mesenchymal Transition - drug effects Hedgehog Proteins - metabolism Humans Isoquinolines - pharmacology Mice Nanog Homeobox Protein - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oxidative Stress - drug effects Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Signal Transduction - drug effects Spheroids, Cellular - drug effects Zinc Finger Protein GLI1 - metabolism
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