Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2

Pulmonary arterial hypertension (PAH) is characterized by abnormal growth and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms underlying alterations in energy production have not been identified. Here, we examined the miRNA and proteomic profiles of blood outgrowth...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2017-12, Vol.136 (25), p.2451-2467
Hauptverfasser:	Caruso, Paola, Dunmore, Benjamin J, Schlosser, Kenny, Schoors, Sandra, Dos Santos, Claudia, Perez-Iratxeta, Carol, Lavoie, Jessie R, Zhang, Hui, Long, Lu, Flockton, Amanda R, Frid, Maria G, Upton, Paul D, D'Alessandro, Angelo, Hadinnapola, Charaka, Kiskin, Fedir N, Taha, Mohamad, Hurst, Liam A, Ormiston, Mark L, Hata, Akiko, Stenmark, Kurt R, Carmeliet, Peter, Stewart, Duncan J, Morrell, Nicholas W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagomirs - metabolism Bone Morphogenetic Protein Receptors, Type II - antagonists & inhibitors Bone Morphogenetic Protein Receptors, Type II - genetics Bone Morphogenetic Protein Receptors, Type II - metabolism Cell Proliferation Cells, Cultured Disease Models, Animal Endothelial Cells - cytology Endothelial Cells - metabolism Familial Primary Pulmonary Hypertension - genetics Familial Primary Pulmonary Hypertension - metabolism Familial Primary Pulmonary Hypertension - pathology Glycolysis Heterogeneous-Nuclear Ribonucleoproteins - antagonists & inhibitors Heterogeneous-Nuclear Ribonucleoproteins - genetics Heterogeneous-Nuclear Ribonucleoproteins - metabolism Humans Lim Kinases - metabolism MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Monocarboxylic Acid Transporters - metabolism Polypyrimidine Tract-Binding Protein - antagonists & inhibitors Polypyrimidine Tract-Binding Protein - genetics Polypyrimidine Tract-Binding Protein - metabolism Pyruvate Kinase - genetics Pyruvate Kinase - metabolism Rats RNA Interference RNA, Small Interfering - metabolism Smad1 Protein - metabolism Smad5 Protein - metabolism Symporters - metabolism
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