Bispecific Antibody Pretargeting of Tumor Neovasculature for Improved Systemic Radiotherapy of Solid Tumors

Purpose: Extra domain B (ED-B) fibronectin is a specific tumor matrix marker for targeting angiogenesis in solid tumors. In this study, the radiotherapeutic potential of the directly radioiodinated divalent anti-ED-B antibody fragment, L19 small immunoprotein (L19-SIP; 75,000 Da), was compared with...

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Veröffentlicht in:	Clinical cancer research 2006-09, Vol.12 (18), p.5587-5595
Hauptverfasser:	MOOSMAYER, Dieter, BERNDORFF, Dietmar, DINKELBORG, Ludger M, CHANG, Chien-Hsing, SHARKEY, Robert M, ROTHER, Axel, BORKOWSKI, Sandra, ROSSI, Edmund A, MCBRIDE, William J, CARDILLO, Thomas M, GOLDENBERG, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Antibodies, Bispecific - administration & dosage Antibodies, Bispecific - chemistry Antibodies, Bispecific - pharmacokinetics Antibodies, Bispecific - therapeutic use Antibodies, Neoplasm - analysis Antigens, Neoplasm - analysis Antineoplastic agents Biological and medical sciences bispecific antibody Drug Delivery Systems - methods ED-B fibronectin Female Glioblastoma - radiotherapy Humans Iodine Radioisotopes - administration & dosage Iodine Radioisotopes - pharmacokinetics Medical sciences Metabolic Clearance Rate - radiation effects Mice Mice, Nude Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neovascularization, Pathologic - radiotherapy Pharmacology. Drug treatments pretargeting Radiation Dosage Radioimmunotherapy - methods radiotherapy Tissue Distribution tumor vasculature Tumors Xenograft Model Antitumor Assays - methods
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