Sugihiratake Mushroom (Angel's Wing Mushroom)-Induced Cryptogenic Encephalopathy may Involve Vitamin D Analogues
In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in ‘Probably Toxi...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2006, Vol.29(12), pp.2514-2518 |
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| creator | Sasaki, Hideki Akiyama, Hiroshi Yoshida, Yoshifumi Kondo, Kazunari Amakura, Yoshiaki Kasahara, Yoshimasa Maitani, Tamio |
| description | In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in ‘Probably Toxic’ sugihiratake collected from the area of encephalopathy outbreaks, and ‘Probably Safe’ sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10 g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia. |
| doi_str_mv | 10.1248/bpb.29.2514 |
| format | Article |
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To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in ‘Probably Toxic’ sugihiratake collected from the area of encephalopathy outbreaks, and ‘Probably Safe’ sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10 g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.29.2514</identifier><identifier>PMID: 17142993</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Agaricales ; Brain Diseases - etiology ; encephalopathy ; Foodborne Diseases ; Humans ; Mass Spectrometry ; multivariate analysis ; sugihiratake ; time-of-flight (ToF)-MS ; ultra performance liquid chromatography (UPLC) ; vitamin D ; Vitamin D - analogs & derivatives</subject><ispartof>Biological and Pharmaceutical Bulletin, 2006, Vol.29(12), pp.2514-2518</ispartof><rights>2006 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-dcb4df9dd496b4f97d07b9f8be60eb556acfdbd9b2ee535ebbc8fb3f4f6b49113</citedby><cites>FETCH-LOGICAL-c532t-dcb4df9dd496b4f97d07b9f8be60eb556acfdbd9b2ee535ebbc8fb3f4f6b49113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17142993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasaki, Hideki</creatorcontrib><creatorcontrib>Akiyama, Hiroshi</creatorcontrib><creatorcontrib>Yoshida, Yoshifumi</creatorcontrib><creatorcontrib>Kondo, Kazunari</creatorcontrib><creatorcontrib>Amakura, Yoshiaki</creatorcontrib><creatorcontrib>Kasahara, Yoshimasa</creatorcontrib><creatorcontrib>Maitani, Tamio</creatorcontrib><title>Sugihiratake Mushroom (Angel's Wing Mushroom)-Induced Cryptogenic Encephalopathy may Involve Vitamin D Analogues</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. 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Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.</description><subject>Agaricales</subject><subject>Brain Diseases - etiology</subject><subject>encephalopathy</subject><subject>Foodborne Diseases</subject><subject>Humans</subject><subject>Mass Spectrometry</subject><subject>multivariate analysis</subject><subject>sugihiratake</subject><subject>time-of-flight (ToF)-MS</subject><subject>ultra performance liquid chromatography (UPLC)</subject><subject>vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c1v0zAYBnALgVgZnLgjS0iDCaXEX0l8LGWDSkM7bMAx8sebj5I4wU4m9b-fq3ZF4mJL9k-PX_lB6C1Jl4Ty4rMe9ZLKJRWEP0MLwnieCErEc7RIJSmSjIjiDL0KYZumaZ5S9hKdkZxwKiVboPFurtum9WpSfwD_mEPjh6HHH1euhu5DwL9bV5-OL5ONs7MBi9d-N05DDa41-MoZGBvVDaOamh3u1Q5v3MPQPQD-1U6qbx3-ilcugnqG8Bq9qFQX4M1xP0c_r6_u19-Tm9tvm_XqJjGC0SmxRnNbSWu5zDSvZG7TXMuq0JCloIXIlKmstlJTAMEEaG2KSrOKV5FLQtg5ujjkjn74G9-dyr4NBrpOORjmUBLJM8aKPXz_H9wOs4_jRsO5ZKIgGY_q00EZP4TgoSpH3_bK70qSlvsaylhDSWW5ryHqd8fMWfdg_9njv0fw5QC2YVI1nIDyU2s6eAoj9GmNqadL0yhfgmOPIxucsg</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Sasaki, Hideki</creator><creator>Akiyama, Hiroshi</creator><creator>Yoshida, Yoshifumi</creator><creator>Kondo, Kazunari</creator><creator>Amakura, Yoshiaki</creator><creator>Kasahara, Yoshimasa</creator><creator>Maitani, Tamio</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7U7</scope><scope>C1K</scope><scope>M7N</scope></search><sort><creationdate>20061201</creationdate><title>Sugihiratake Mushroom (Angel's Wing Mushroom)-Induced Cryptogenic Encephalopathy may Involve Vitamin D Analogues</title><author>Sasaki, Hideki ; Akiyama, Hiroshi ; Yoshida, Yoshifumi ; Kondo, Kazunari ; Amakura, Yoshiaki ; Kasahara, Yoshimasa ; Maitani, Tamio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-dcb4df9dd496b4f97d07b9f8be60eb556acfdbd9b2ee535ebbc8fb3f4f6b49113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Agaricales</topic><topic>Brain Diseases - etiology</topic><topic>encephalopathy</topic><topic>Foodborne Diseases</topic><topic>Humans</topic><topic>Mass Spectrometry</topic><topic>multivariate analysis</topic><topic>sugihiratake</topic><topic>time-of-flight (ToF)-MS</topic><topic>ultra performance liquid chromatography (UPLC)</topic><topic>vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasaki, Hideki</creatorcontrib><creatorcontrib>Akiyama, Hiroshi</creatorcontrib><creatorcontrib>Yoshida, Yoshifumi</creatorcontrib><creatorcontrib>Kondo, Kazunari</creatorcontrib><creatorcontrib>Amakura, Yoshiaki</creatorcontrib><creatorcontrib>Kasahara, Yoshimasa</creatorcontrib><creatorcontrib>Maitani, Tamio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasaki, Hideki</au><au>Akiyama, Hiroshi</au><au>Yoshida, Yoshifumi</au><au>Kondo, Kazunari</au><au>Amakura, Yoshiaki</au><au>Kasahara, Yoshimasa</au><au>Maitani, Tamio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sugihiratake Mushroom (Angel's Wing Mushroom)-Induced Cryptogenic Encephalopathy may Involve Vitamin D Analogues</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>29</volume><issue>12</issue><spage>2514</spage><epage>2518</epage><pages>2514-2518</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. 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| subjects | Agaricales Brain Diseases - etiology encephalopathy Foodborne Diseases Humans Mass Spectrometry multivariate analysis sugihiratake time-of-flight (ToF)-MS ultra performance liquid chromatography (UPLC) vitamin D Vitamin D - analogs & derivatives |
| title | Sugihiratake Mushroom (Angel's Wing Mushroom)-Induced Cryptogenic Encephalopathy may Involve Vitamin D Analogues |
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