Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery

In this paper, a novel drug carrier for brain delivery, cationic bovine serum albumin (CBSA) conjugated with poly(ethyleneglycol)–poly(lactide) (PEG–PLA) nanoparticle (CBSA–NP), was developed and its effects were evaluated. The copolymers of methoxy-PEG–PLA and maleimide-PEG–PLA were synthesized by...

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Veröffentlicht in:	Journal of controlled release 2005-10, Vol.107 (3), p.428-448
Hauptverfasser:	Lu, Wei, Zhang, Yan, Tan, Yu-Zhen, Hu, Kai-Li, Jiang, Xin-Guo, Fu, Shou-Kuan
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Coumarin Albumins - chemistry Animals Biological and medical sciences Blood–brain barrier (BBB) Brain - metabolism Brain delivery Capillaries - cytology Capillaries - metabolism Cationic bovine serum albumin (CBSA) Cations Cell Survival - drug effects Coumarins - administration & dosage Coumarins - chemistry Drug Carriers Drug Delivery Systems Electrochemistry Endothelial Cells - metabolism General pharmacology Immunohistochemistry Maleimides - chemistry Medical sciences Mice Microscopy, Electron Microscopy, Fluorescence Nanostructures Nephelometry and Turbidimetry Particle Size Pegylated nanoparticle Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - chemistry Rats Serum Albumin, Bovine X-Ray Diffraction
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