Preparation, characterization and nasal delivery of α-cobrotoxin-loaded poly(lactide- co-glycolide)/polyanhydride microspheres

In this study, α-cobrotoxin was incorporated into the microspheres composed of poly(lactide- co-glycolide) (PLGA) and poly[1,3-bis( p-carboxy-phenoxy) propane- co– p-(carboxyethylformamido) benzoic anhydride] (P(CPP:CEFB)) and intranasally delivered to model rats in order to improve its analgesic ac...

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Veröffentlicht in:	Journal of controlled release 2005-11, Vol.108 (1), p.10-20
Hauptverfasser:	Li, Y., Jiang, H.L., Zhu, K.J., Liu, J.H., Hao, Y.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - chemistry Analgesics, Non-Narcotic - therapeutic use Animals Bioadhesion Biological and medical sciences Cobra Neurotoxin Proteins - administration & dosage Cobra Neurotoxin Proteins - chemistry Cobra Neurotoxin Proteins - therapeutic use Drug Compounding Drug Delivery Systems Drug Stability General pharmacology Male Medical sciences Microsphere Microspheres Nasal delivery Nasal Mucosa - drug effects Nasal Mucosa - metabolism Nasal Mucosa - pathology Pain - drug therapy Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyanhydride Polyglactin 910 - chemistry Rats Rats, Wistar Solubility Time Factors α-Cobrotoxin
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